Abstract
Five new triterpenoid saponins, pursaethosides A-E (1-5), were isolated from the η-BuOH extract of the seed kernels of Entada pursaetha along with the known phaseoloidin. The structures of 1-5 were elucidated mainly by spectroscopic data interpretation and chemical degradation. Pursaethosides C-E (3-5) possess as a common structural feature entagenic acid as aglycon, which is rare among triterpene saponins. Compounds 2-4 and phaesolidin were found to be not cytotoxic when tested against HCT 116 and HT-29 human colon cancer cells.
| Original language | English |
|---|---|
| Pages (from-to) | 1185-1190 |
| Number of pages | 6 |
| Journal | Journal of Natural Products |
| Volume | 68 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 1 2005 |
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All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
Cite this
Pursaethosides A-E, triterpene saponins from Entada pursaetha. / Tapondjou, Azefack Léon; Miyamoto, Tomofumi; Mirjolet, Jean François; Guilbaud, Nicolas; Lacaille-Dubois, Marie Aleth.
In: Journal of Natural Products, Vol. 68, No. 8, 01.08.2005, p. 1185-1190.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pursaethosides A-E, triterpene saponins from Entada pursaetha
AU - Tapondjou, Azefack Léon
AU - Miyamoto, Tomofumi
AU - Mirjolet, Jean François
AU - Guilbaud, Nicolas
AU - Lacaille-Dubois, Marie Aleth
PY - 2005/8/1
Y1 - 2005/8/1
N2 - Five new triterpenoid saponins, pursaethosides A-E (1-5), were isolated from the η-BuOH extract of the seed kernels of Entada pursaetha along with the known phaseoloidin. The structures of 1-5 were elucidated mainly by spectroscopic data interpretation and chemical degradation. Pursaethosides C-E (3-5) possess as a common structural feature entagenic acid as aglycon, which is rare among triterpene saponins. Compounds 2-4 and phaesolidin were found to be not cytotoxic when tested against HCT 116 and HT-29 human colon cancer cells.
AB - Five new triterpenoid saponins, pursaethosides A-E (1-5), were isolated from the η-BuOH extract of the seed kernels of Entada pursaetha along with the known phaseoloidin. The structures of 1-5 were elucidated mainly by spectroscopic data interpretation and chemical degradation. Pursaethosides C-E (3-5) possess as a common structural feature entagenic acid as aglycon, which is rare among triterpene saponins. Compounds 2-4 and phaesolidin were found to be not cytotoxic when tested against HCT 116 and HT-29 human colon cancer cells.
UR - http://www.scopus.com/inward/record.url?scp=24744459626&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=24744459626&partnerID=8YFLogxK
U2 - 10.1021/np0580311
DO - 10.1021/np0580311
M3 - Article
C2 - 16124758
AN - SCOPUS:24744459626
VL - 68
SP - 1185
EP - 1190
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 8
ER -