Pursaethosides A-E, triterpene saponins from Entada pursaetha

Azefack Léon Tapondjou, Tomofumi Miyamoto, Jean François Mirjolet, Nicolas Guilbaud, Marie Aleth Lacaille-Dubois

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Five new triterpenoid saponins, pursaethosides A-E (1-5), were isolated from the η-BuOH extract of the seed kernels of Entada pursaetha along with the known phaseoloidin. The structures of 1-5 were elucidated mainly by spectroscopic data interpretation and chemical degradation. Pursaethosides C-E (3-5) possess as a common structural feature entagenic acid as aglycon, which is rare among triterpene saponins. Compounds 2-4 and phaesolidin were found to be not cytotoxic when tested against HCT 116 and HT-29 human colon cancer cells.

Original languageEnglish
Pages (from-to)1185-1190
Number of pages6
JournalJournal of Natural Products
Volume68
Issue number8
DOIs
Publication statusPublished - Aug 1 2005

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Triterpenes
Saponins
Colonic Neoplasms
Seed
Seeds
Cells
Degradation
Acids

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Tapondjou, A. L., Miyamoto, T., Mirjolet, J. F., Guilbaud, N., & Lacaille-Dubois, M. A. (2005). Pursaethosides A-E, triterpene saponins from Entada pursaetha. Journal of Natural Products, 68(8), 1185-1190. https://doi.org/10.1021/np0580311

Pursaethosides A-E, triterpene saponins from Entada pursaetha. / Tapondjou, Azefack Léon; Miyamoto, Tomofumi; Mirjolet, Jean François; Guilbaud, Nicolas; Lacaille-Dubois, Marie Aleth.

In: Journal of Natural Products, Vol. 68, No. 8, 01.08.2005, p. 1185-1190.

Research output: Contribution to journalArticle

Tapondjou, AL, Miyamoto, T, Mirjolet, JF, Guilbaud, N & Lacaille-Dubois, MA 2005, 'Pursaethosides A-E, triterpene saponins from Entada pursaetha', Journal of Natural Products, vol. 68, no. 8, pp. 1185-1190. https://doi.org/10.1021/np0580311
Tapondjou AL, Miyamoto T, Mirjolet JF, Guilbaud N, Lacaille-Dubois MA. Pursaethosides A-E, triterpene saponins from Entada pursaetha. Journal of Natural Products. 2005 Aug 1;68(8):1185-1190. https://doi.org/10.1021/np0580311
Tapondjou, Azefack Léon ; Miyamoto, Tomofumi ; Mirjolet, Jean François ; Guilbaud, Nicolas ; Lacaille-Dubois, Marie Aleth. / Pursaethosides A-E, triterpene saponins from Entada pursaetha. In: Journal of Natural Products. 2005 ; Vol. 68, No. 8. pp. 1185-1190.
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