Pursaethosides A-E, triterpene saponins from Entada pursaetha

Azefack Léon Tapondjou; Tomofumi Miyamoto; Jean François Mirjolet; Nicolas Guilbaud; Marie Aleth Lacaille-Dubois

doi:10.1021/np0580311

Pursaethosides A-E, triterpene saponins from Entada pursaetha

Azefack Léon Tapondjou, Tomofumi Miyamoto, Jean François Mirjolet, Nicolas Guilbaud, Marie Aleth Lacaille-Dubois

Pharmaceutical Health Care and Sciences

Research output: Contribution to journal › Article

40 Citations (Scopus)

Abstract

Five new triterpenoid saponins, pursaethosides A-E (1-5), were isolated from the η-BuOH extract of the seed kernels of Entada pursaetha along with the known phaseoloidin. The structures of 1-5 were elucidated mainly by spectroscopic data interpretation and chemical degradation. Pursaethosides C-E (3-5) possess as a common structural feature entagenic acid as aglycon, which is rare among triterpene saponins. Compounds 2-4 and phaesolidin were found to be not cytotoxic when tested against HCT 116 and HT-29 human colon cancer cells.

Original language	English
Pages (from-to)	1185-1190
Number of pages	6
Journal	Journal of Natural Products
Volume	68
Issue number	8
DOIs	https://doi.org/10.1021/np0580311
Publication status	Published - Aug 1 2005

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All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Cite this

Tapondjou, A. L., Miyamoto, T., Mirjolet, J. F., Guilbaud, N., & Lacaille-Dubois, M. A. (2005). Pursaethosides A-E, triterpene saponins from Entada pursaetha. Journal of Natural Products, 68(8), 1185-1190. https://doi.org/10.1021/np0580311

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10.1021/np0580311