Pursaethosides A-E, triterpene saponins from Entada pursaetha

Azefack Léon Tapondjou; Tomofumi Miyamoto; Jean François Mirjolet; Nicolas Guilbaud; Marie Aleth Lacaille-Dubois

doi:10.1021/np0580311

Pursaethosides A-E, triterpene saponins from Entada pursaetha

Azefack Léon Tapondjou, Tomofumi Miyamoto, Jean François Mirjolet, Nicolas Guilbaud, Marie Aleth Lacaille-Dubois

Pharmaceutical Health Care and Sciences

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

Five new triterpenoid saponins, pursaethosides A-E (1-5), were isolated from the η-BuOH extract of the seed kernels of Entada pursaetha along with the known phaseoloidin. The structures of 1-5 were elucidated mainly by spectroscopic data interpretation and chemical degradation. Pursaethosides C-E (3-5) possess as a common structural feature entagenic acid as aglycon, which is rare among triterpene saponins. Compounds 2-4 and phaesolidin were found to be not cytotoxic when tested against HCT 116 and HT-29 human colon cancer cells.

Original language	English
Pages (from-to)	1185-1190
Number of pages	6
Journal	Journal of Natural Products
Volume	68
Issue number	8
DOIs	https://doi.org/10.1021/np0580311
Publication status	Published - Aug 1 2005

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np0580311

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abstract = "Five new triterpenoid saponins, pursaethosides A-E (1-5), were isolated from the η-BuOH extract of the seed kernels of Entada pursaetha along with the known phaseoloidin. The structures of 1-5 were elucidated mainly by spectroscopic data interpretation and chemical degradation. Pursaethosides C-E (3-5) possess as a common structural feature entagenic acid as aglycon, which is rare among triterpene saponins. Compounds 2-4 and phaesolidin were found to be not cytotoxic when tested against HCT 116 and HT-29 human colon cancer cells.",

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AU - Tapondjou, Azefack Léon

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AU - Guilbaud, Nicolas

AU - Lacaille-Dubois, Marie Aleth

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