Pursaethosides A-E, triterpene saponins from Entada pursaetha

Azefack Léon Tapondjou, Tomofumi Miyamoto, Jean François Mirjolet, Nicolas Guilbaud, Marie Aleth Lacaille-Dubois

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40 Citations (Scopus)

Abstract

Five new triterpenoid saponins, pursaethosides A-E (1-5), were isolated from the η-BuOH extract of the seed kernels of Entada pursaetha along with the known phaseoloidin. The structures of 1-5 were elucidated mainly by spectroscopic data interpretation and chemical degradation. Pursaethosides C-E (3-5) possess as a common structural feature entagenic acid as aglycon, which is rare among triterpene saponins. Compounds 2-4 and phaesolidin were found to be not cytotoxic when tested against HCT 116 and HT-29 human colon cancer cells.

Original languageEnglish
Pages (from-to)1185-1190
Number of pages6
JournalJournal of Natural Products
Volume68
Issue number8
DOIs
Publication statusPublished - Aug 1 2005

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All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Tapondjou, A. L., Miyamoto, T., Mirjolet, J. F., Guilbaud, N., & Lacaille-Dubois, M. A. (2005). Pursaethosides A-E, triterpene saponins from Entada pursaetha. Journal of Natural Products, 68(8), 1185-1190. https://doi.org/10.1021/np0580311