Abstract
A 66-year-old woman presented after an episode of accidental trauma with a painful ulcer on her scalp which rapidly enlarged in size, accompanied by central necrosis and undermining ulceration. The patient's past history was negative for underlying systemic disease, although she had had a similar post-traumatic intractable leg ulcer 3 years prior, which was unresponsive to surgical management but successfully treated with systemic steroids. A biopsied specimen from the scalp showed marked neutrophilic infiltrates in the dermis, compatible with a diagnosis of pyoderma gangrenosum (PG). The large ulcerative lesion responded very well to oral steroid therapy, showing rapid epithelialization. Serum levels of granulocyte colony-stimulating factor and interleukin-6 were significantly elevated prior to treatment, with decrease to normal levels after treatment. Serum tumor necrosis factor (TNF)-α and granulocyte macrophage colony-stimulating factor levels were within normal limits. The significance and pathogenic role of cytokine burst in PG is reviewed and discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 1186-1188 |
| Number of pages | 3 |
| Journal | Journal of Dermatology |
| Volume | 42 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 1 2015 |
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All Science Journal Classification (ASJC) codes
- Dermatology
Cite this
Pyoderma gangrenosum with increased levels of serum cytokines. / Kozono, Kana; Nakahara, Takeshi; Kikuchi, Satoko; Itoh, Eriko; Kido-Nakahara, Makiko; Furue, Masutaka.
In: Journal of Dermatology, Vol. 42, No. 12, 01.12.2015, p. 1186-1188.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Pyoderma gangrenosum with increased levels of serum cytokines
AU - Kozono, Kana
AU - Nakahara, Takeshi
AU - Kikuchi, Satoko
AU - Itoh, Eriko
AU - Kido-Nakahara, Makiko
AU - Furue, Masutaka
PY - 2015/12/1
Y1 - 2015/12/1
N2 - A 66-year-old woman presented after an episode of accidental trauma with a painful ulcer on her scalp which rapidly enlarged in size, accompanied by central necrosis and undermining ulceration. The patient's past history was negative for underlying systemic disease, although she had had a similar post-traumatic intractable leg ulcer 3 years prior, which was unresponsive to surgical management but successfully treated with systemic steroids. A biopsied specimen from the scalp showed marked neutrophilic infiltrates in the dermis, compatible with a diagnosis of pyoderma gangrenosum (PG). The large ulcerative lesion responded very well to oral steroid therapy, showing rapid epithelialization. Serum levels of granulocyte colony-stimulating factor and interleukin-6 were significantly elevated prior to treatment, with decrease to normal levels after treatment. Serum tumor necrosis factor (TNF)-α and granulocyte macrophage colony-stimulating factor levels were within normal limits. The significance and pathogenic role of cytokine burst in PG is reviewed and discussed.
AB - A 66-year-old woman presented after an episode of accidental trauma with a painful ulcer on her scalp which rapidly enlarged in size, accompanied by central necrosis and undermining ulceration. The patient's past history was negative for underlying systemic disease, although she had had a similar post-traumatic intractable leg ulcer 3 years prior, which was unresponsive to surgical management but successfully treated with systemic steroids. A biopsied specimen from the scalp showed marked neutrophilic infiltrates in the dermis, compatible with a diagnosis of pyoderma gangrenosum (PG). The large ulcerative lesion responded very well to oral steroid therapy, showing rapid epithelialization. Serum levels of granulocyte colony-stimulating factor and interleukin-6 were significantly elevated prior to treatment, with decrease to normal levels after treatment. Serum tumor necrosis factor (TNF)-α and granulocyte macrophage colony-stimulating factor levels were within normal limits. The significance and pathogenic role of cytokine burst in PG is reviewed and discussed.
UR - http://www.scopus.com/inward/record.url?scp=84955178499&partnerID=8YFLogxK
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U2 - 10.1111/1346-8138.12970
DO - 10.1111/1346-8138.12970
M3 - Article
C2 - 26047254
AN - SCOPUS:84955178499
VL - 42
SP - 1186
EP - 1188
JO - Journal of Dermatology
JF - Journal of Dermatology
SN - 0385-2407
IS - 12
ER -