Quality of life of patients with osteonecrosis of the femoral head: a multicentre study

Yuko Uesugi, Takashi Sakai, Taisuke Seki, Shinya Hayashi, Junichi Nakamura, Yutaka Inaba, Daisuke Takahashi, Kan Sasaki, Goro Motomura, Naohiko Mashima, Tamon Kabata, Akihiro Sudo, Tetsuya Jinno, Wataru Ando, Satoshi Nagoya, Kengo Yamamoto, Satoshi Nakasone, Hiroshi Ito, Takuaki Yamamoto, Nobuhiko Sugano

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Purpose: Quality-of-life (QOL) assessments in patients with osteonecrosis of the femoral head (ONFH) have rarely been reported. This multicentre study aimed to elucidate the relationship between disease severity, including necrotic lesion type and radiological staging, and QOL, as well as between patients’ characteristics and QOL. Methods: Two hundred seventy-four patients with ONFH (108 females, 166 males; median age, 46 years) were asked to complete self-assessment QOL questionnaires including the Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire, Oxford Hip Score, and SF-12v2. Results: Patients with large necrotic lesion type or collapsed ONFH had low QOL scores. Among patients with non-collapsed lesions, patients with alcohol-associated ONFH had lower QOL scores than those with steroid-associated ONFH, those with bilateral ONFH had lower mental scores, and male patients had worse social condition scores. Among patients with collapsed lesions, middle-aged patients exhibited lower mental QOL, and a strong correlation was observed between social activity and mental health. Conclusion: Collapsed ONFH was associated with low QOL scores. Among patients with non-collapsed lesions, alcohol-associated ONFH, bilateral disease, and male sex were linked to low QOL scores.

Original languageEnglish
Pages (from-to)1517-1525
Number of pages9
JournalInternational Orthopaedics
Issue number7
Publication statusPublished - Jul 1 2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Orthopedics and Sports Medicine


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