Quantification of adverse effects of regular use of triazolam on clinical outcomes for older people with insomnia: A retrospective cohort study

Toshiki Maeda, Akira Babazono, Takumi Nishi, Midori Yasui

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective Older people are more likely to have insomnia. One of the most prescribed hypnotics in Japan is triazolam. Although some studies showed the possibility of adverse effects of triazolam in older people, there have been few studies investigating these effects in a clinical setting. The aim of this study was to determine whether patients who used triazolam regularly had increased risks of pneumonia, trauma, and pressure ulcers. Methods The research design was a retrospective cohort study using claim data. The subjects of the study were patients who were insured by Fukuoka Late Stage Elderly Healthcare Insurance. We defined patients who had received triazolam for 180 days or longer during fiscal year 2011 as the triazolam group, and those who had not received any hypnotics during the period as the non-triazolam group. Each patient in the triazolam group was then matched with a unique control from the non-triazolam group according to propensity score. Multivariate conditional logistic regression analyses were used to obtain adjusted odds ratios for pneumonia, trauma, and pressure ulcer in the triazolam group compared with the non-triazolam group. Results The number of patients in the triazolam and non-triazolam groups in the unmatched cohort was 13,015 and 411,610, respectively. Adjusted odds ratios show that the risks for pneumonia, trauma, and pressure ulcer in the matched cohort increased by approximately 40%, 30%, and slightly less than 30%, respectively (all statistically significant). Conclusions Regular use of triazolam is a risk factor for pneumonia, trauma, and pressure ulcer in older people.

Original languageEnglish
Pages (from-to)186-194
Number of pages9
JournalInternational Journal of Geriatric Psychiatry
Volume31
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

Fingerprint

Triazolam
Sleep Initiation and Maintenance Disorders
Cohort Studies
Retrospective Studies
Pressure Ulcer
Pneumonia
Wounds and Injuries
Hypnotics and Sedatives
Odds Ratio
Propensity Score
Insurance
Japan
Research Design
Logistic Models
Regression Analysis
Delivery of Health Care

All Science Journal Classification (ASJC) codes

  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Quantification of adverse effects of regular use of triazolam on clinical outcomes for older people with insomnia : A retrospective cohort study. / Maeda, Toshiki; Babazono, Akira; Nishi, Takumi; Yasui, Midori.

In: International Journal of Geriatric Psychiatry, Vol. 31, No. 2, 01.02.2016, p. 186-194.

Research output: Contribution to journalArticle

@article{be109825fa2d42f0885a3ba42cd6d4ff,
title = "Quantification of adverse effects of regular use of triazolam on clinical outcomes for older people with insomnia: A retrospective cohort study",
abstract = "Objective Older people are more likely to have insomnia. One of the most prescribed hypnotics in Japan is triazolam. Although some studies showed the possibility of adverse effects of triazolam in older people, there have been few studies investigating these effects in a clinical setting. The aim of this study was to determine whether patients who used triazolam regularly had increased risks of pneumonia, trauma, and pressure ulcers. Methods The research design was a retrospective cohort study using claim data. The subjects of the study were patients who were insured by Fukuoka Late Stage Elderly Healthcare Insurance. We defined patients who had received triazolam for 180 days or longer during fiscal year 2011 as the triazolam group, and those who had not received any hypnotics during the period as the non-triazolam group. Each patient in the triazolam group was then matched with a unique control from the non-triazolam group according to propensity score. Multivariate conditional logistic regression analyses were used to obtain adjusted odds ratios for pneumonia, trauma, and pressure ulcer in the triazolam group compared with the non-triazolam group. Results The number of patients in the triazolam and non-triazolam groups in the unmatched cohort was 13,015 and 411,610, respectively. Adjusted odds ratios show that the risks for pneumonia, trauma, and pressure ulcer in the matched cohort increased by approximately 40{\%}, 30{\%}, and slightly less than 30{\%}, respectively (all statistically significant). Conclusions Regular use of triazolam is a risk factor for pneumonia, trauma, and pressure ulcer in older people.",
author = "Toshiki Maeda and Akira Babazono and Takumi Nishi and Midori Yasui",
year = "2016",
month = "2",
day = "1",
doi = "10.1002/gps.4310",
language = "English",
volume = "31",
pages = "186--194",
journal = "International Journal of Geriatric Psychiatry",
issn = "0885-6230",
publisher = "John Wiley and Sons Ltd",
number = "2",

}

TY - JOUR

T1 - Quantification of adverse effects of regular use of triazolam on clinical outcomes for older people with insomnia

T2 - A retrospective cohort study

AU - Maeda, Toshiki

AU - Babazono, Akira

AU - Nishi, Takumi

AU - Yasui, Midori

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Objective Older people are more likely to have insomnia. One of the most prescribed hypnotics in Japan is triazolam. Although some studies showed the possibility of adverse effects of triazolam in older people, there have been few studies investigating these effects in a clinical setting. The aim of this study was to determine whether patients who used triazolam regularly had increased risks of pneumonia, trauma, and pressure ulcers. Methods The research design was a retrospective cohort study using claim data. The subjects of the study were patients who were insured by Fukuoka Late Stage Elderly Healthcare Insurance. We defined patients who had received triazolam for 180 days or longer during fiscal year 2011 as the triazolam group, and those who had not received any hypnotics during the period as the non-triazolam group. Each patient in the triazolam group was then matched with a unique control from the non-triazolam group according to propensity score. Multivariate conditional logistic regression analyses were used to obtain adjusted odds ratios for pneumonia, trauma, and pressure ulcer in the triazolam group compared with the non-triazolam group. Results The number of patients in the triazolam and non-triazolam groups in the unmatched cohort was 13,015 and 411,610, respectively. Adjusted odds ratios show that the risks for pneumonia, trauma, and pressure ulcer in the matched cohort increased by approximately 40%, 30%, and slightly less than 30%, respectively (all statistically significant). Conclusions Regular use of triazolam is a risk factor for pneumonia, trauma, and pressure ulcer in older people.

AB - Objective Older people are more likely to have insomnia. One of the most prescribed hypnotics in Japan is triazolam. Although some studies showed the possibility of adverse effects of triazolam in older people, there have been few studies investigating these effects in a clinical setting. The aim of this study was to determine whether patients who used triazolam regularly had increased risks of pneumonia, trauma, and pressure ulcers. Methods The research design was a retrospective cohort study using claim data. The subjects of the study were patients who were insured by Fukuoka Late Stage Elderly Healthcare Insurance. We defined patients who had received triazolam for 180 days or longer during fiscal year 2011 as the triazolam group, and those who had not received any hypnotics during the period as the non-triazolam group. Each patient in the triazolam group was then matched with a unique control from the non-triazolam group according to propensity score. Multivariate conditional logistic regression analyses were used to obtain adjusted odds ratios for pneumonia, trauma, and pressure ulcer in the triazolam group compared with the non-triazolam group. Results The number of patients in the triazolam and non-triazolam groups in the unmatched cohort was 13,015 and 411,610, respectively. Adjusted odds ratios show that the risks for pneumonia, trauma, and pressure ulcer in the matched cohort increased by approximately 40%, 30%, and slightly less than 30%, respectively (all statistically significant). Conclusions Regular use of triazolam is a risk factor for pneumonia, trauma, and pressure ulcer in older people.

UR - http://www.scopus.com/inward/record.url?scp=84954078393&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84954078393&partnerID=8YFLogxK

U2 - 10.1002/gps.4310

DO - 10.1002/gps.4310

M3 - Article

C2 - 26042655

AN - SCOPUS:84954078393

VL - 31

SP - 186

EP - 194

JO - International Journal of Geriatric Psychiatry

JF - International Journal of Geriatric Psychiatry

SN - 0885-6230

IS - 2

ER -