Quantification of ex vivo tissue activity by short and long time-course analysis of multifunctional OCT signals

I. G. Abd El-Sadek, A. Miyazawa, L. T.W. Shen, S. Fukuda, T. Yamashita, Y. Oka, P. Mukherjee, S. Makita, S. Matsusaka, T. Oshika, H. Kano, Y. Yasuno

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We present a new OCT-based tissue dynamics/subcellular motion analysis method to visualize tissue dynamics, where we increase the functionality of OCT to be sensitive for tissue dynamics by utilizing rapid-time-sequence analysis of OCT signals. These analysis includes log intensity variance (LIV) and OCT time-correlation analysis (OCT decorrelation speed; OCDS). In addition to LIV and OCDS methods, attenuation coefficient (AC), birefringence, and degree of polarization uniformity (DOPU) analysis were performed. These methods used to visualize and quantify long-term tissue dynamics degradation of different tissue types such as dissected mouse liver and tumor spheroids. These methods were quantitative, so the time-course tissue dynamics degradation has been not only visualized as an image, but also quantitative analysis of the dynamics degradation were performed.

Original languageEnglish
Title of host publicationOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV
EditorsJoseph A. Izatt, James G. Fujimoto
PublisherSPIE
ISBN (Electronic)9781510632196
DOIs
Publication statusPublished - 2020
Externally publishedYes
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV 2020 - San Francisco, United States
Duration: Feb 3 2020Feb 5 2020

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11228
ISSN (Print)1605-7422

Conference

ConferenceOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV 2020
CountryUnited States
CitySan Francisco
Period2/3/202/5/20

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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