Quantification of regional myocardial blood flow estimation with three-dimensional dynamic rubidium-82 PET and modified spillover correction model

Chietsugu Katoh, Keiichiro Yoshinaga, Ran Klein, Katsuhiko Kasai, Yuuki Tomiyama, Osamu Manabe, Masanao Naya, Mamoru Sakakibara, Hiroyuki Tsutsui, Robert A. DeKemp, Nagara Tamaki

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Purpose. Myocardial blood flow (MBF) estimation with 82Rubidium (82Rb) positron emission tomography (PET) is technically difficult because of the high spillover between regions of interest, especially due to the long positron range. We sought to develop a new algorithm to reduce the spillover in image-derived blood activity curves, using non-uniform weighted leastsquares fitting. Methods. Fourteen volunteers underwent imaging with both 3-dimensional (3D) 82Rb and 15O-water PET at rest and during pharmacological stress. Whole left ventricular (LV) 82Rb MBF was estimated using a one-compartment model, including a myocardium-to-blood spillover correction to estimate the corresponding blood input function Ca(t)whole. Regional K1 values were calculated using this uniform global input function, which simplifies equations and enables robust estimation of MBF. To assess the robustness of the modified algorithm, interoperator repeatability of 3D 82Rb MBF was compared with a previously established method. Results. Whole LV correlation of 82Rb MBF with 15O-water MBF was better (P < .01) with the modified spillover correction method (r = 0.92 vs r = 0.60). The modified method also yielded significantly improved inter-operator repeatability of regional MBF quantification (r = 0.89) versus the established method (r = 0.82) (P < .01). Conclusion. A uniform global input function can suppress LV spillover into the imagederived blood input function, resulting in improved precision for MBF quantification with 3D 82Rb PET.

Original languageEnglish
Pages (from-to)763-774
Number of pages12
JournalJournal of Nuclear Cardiology
Volume19
Issue number4
DOIs
Publication statusPublished - Aug 1 2012
Externally publishedYes

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Rubidium
Regional Blood Flow
Positron-Emission Tomography
Water
Volunteers
Myocardium

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Quantification of regional myocardial blood flow estimation with three-dimensional dynamic rubidium-82 PET and modified spillover correction model. / Katoh, Chietsugu; Yoshinaga, Keiichiro; Klein, Ran; Kasai, Katsuhiko; Tomiyama, Yuuki; Manabe, Osamu; Naya, Masanao; Sakakibara, Mamoru; Tsutsui, Hiroyuki; DeKemp, Robert A.; Tamaki, Nagara.

In: Journal of Nuclear Cardiology, Vol. 19, No. 4, 01.08.2012, p. 763-774.

Research output: Contribution to journalArticle

Katoh, C, Yoshinaga, K, Klein, R, Kasai, K, Tomiyama, Y, Manabe, O, Naya, M, Sakakibara, M, Tsutsui, H, DeKemp, RA & Tamaki, N 2012, 'Quantification of regional myocardial blood flow estimation with three-dimensional dynamic rubidium-82 PET and modified spillover correction model', Journal of Nuclear Cardiology, vol. 19, no. 4, pp. 763-774. https://doi.org/10.1007/s12350-012-9558-1
Katoh, Chietsugu ; Yoshinaga, Keiichiro ; Klein, Ran ; Kasai, Katsuhiko ; Tomiyama, Yuuki ; Manabe, Osamu ; Naya, Masanao ; Sakakibara, Mamoru ; Tsutsui, Hiroyuki ; DeKemp, Robert A. ; Tamaki, Nagara. / Quantification of regional myocardial blood flow estimation with three-dimensional dynamic rubidium-82 PET and modified spillover correction model. In: Journal of Nuclear Cardiology. 2012 ; Vol. 19, No. 4. pp. 763-774.
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AU - Katoh, Chietsugu

AU - Yoshinaga, Keiichiro

AU - Klein, Ran

AU - Kasai, Katsuhiko

AU - Tomiyama, Yuuki

AU - Manabe, Osamu

AU - Naya, Masanao

AU - Sakakibara, Mamoru

AU - Tsutsui, Hiroyuki

AU - DeKemp, Robert A.

AU - Tamaki, Nagara

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N2 - Purpose. Myocardial blood flow (MBF) estimation with 82Rubidium (82Rb) positron emission tomography (PET) is technically difficult because of the high spillover between regions of interest, especially due to the long positron range. We sought to develop a new algorithm to reduce the spillover in image-derived blood activity curves, using non-uniform weighted leastsquares fitting. Methods. Fourteen volunteers underwent imaging with both 3-dimensional (3D) 82Rb and 15O-water PET at rest and during pharmacological stress. Whole left ventricular (LV) 82Rb MBF was estimated using a one-compartment model, including a myocardium-to-blood spillover correction to estimate the corresponding blood input function Ca(t)whole. Regional K1 values were calculated using this uniform global input function, which simplifies equations and enables robust estimation of MBF. To assess the robustness of the modified algorithm, interoperator repeatability of 3D 82Rb MBF was compared with a previously established method. Results. Whole LV correlation of 82Rb MBF with 15O-water MBF was better (P < .01) with the modified spillover correction method (r = 0.92 vs r = 0.60). The modified method also yielded significantly improved inter-operator repeatability of regional MBF quantification (r = 0.89) versus the established method (r = 0.82) (P < .01). Conclusion. A uniform global input function can suppress LV spillover into the imagederived blood input function, resulting in improved precision for MBF quantification with 3D 82Rb PET.

AB - Purpose. Myocardial blood flow (MBF) estimation with 82Rubidium (82Rb) positron emission tomography (PET) is technically difficult because of the high spillover between regions of interest, especially due to the long positron range. We sought to develop a new algorithm to reduce the spillover in image-derived blood activity curves, using non-uniform weighted leastsquares fitting. Methods. Fourteen volunteers underwent imaging with both 3-dimensional (3D) 82Rb and 15O-water PET at rest and during pharmacological stress. Whole left ventricular (LV) 82Rb MBF was estimated using a one-compartment model, including a myocardium-to-blood spillover correction to estimate the corresponding blood input function Ca(t)whole. Regional K1 values were calculated using this uniform global input function, which simplifies equations and enables robust estimation of MBF. To assess the robustness of the modified algorithm, interoperator repeatability of 3D 82Rb MBF was compared with a previously established method. Results. Whole LV correlation of 82Rb MBF with 15O-water MBF was better (P < .01) with the modified spillover correction method (r = 0.92 vs r = 0.60). The modified method also yielded significantly improved inter-operator repeatability of regional MBF quantification (r = 0.89) versus the established method (r = 0.82) (P < .01). Conclusion. A uniform global input function can suppress LV spillover into the imagederived blood input function, resulting in improved precision for MBF quantification with 3D 82Rb PET.

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