Quantification of the dynamics of enterovirus 71 infection by experimental-mathematical investigation

Mitsuko Fukuhara, Shingo Iwami, Kei Sato, Yorihiro Nishimura, Hiroyuki Shimizu, Kazuyuki Aihara, Yoshio Koyanagi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Enterovirus 71 (EV71) is the causative agent of hand-foot-and-mouth disease and can trigger neurological disorders. EV71 outbreaks are a major public health concern in Asia-Pacific countries. By performing experimental-mathematical investigation, we demonstrate here that viral productivity and transmissibility but not viral cytotoxicity are drastically different among EV71 strains and can be associated with their epidemiological backgrounds. This is the first report demonstrating the dynamics of nonenveloped virus replication in cell culture using mathematical modeling.

Original languageEnglish
Pages (from-to)701-705
Number of pages5
JournalJournal of virology
Volume87
Issue number1
DOIs
Publication statusPublished - Jan 2013

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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