Quantification of the dynamics of enterovirus 71 infection by experimental-mathematical investigation

Mitsuko Fukuhara, Shingo Iwami, Kei Sato, Yorihiro Nishimura, Hiroyuki Shimizu, Kazuyuki Aihara, Yoshio Koyanagi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Enterovirus 71 (EV71) is the causative agent of hand-foot-and-mouth disease and can trigger neurological disorders. EV71 outbreaks are a major public health concern in Asia-Pacific countries. By performing experimental-mathematical investigation, we demonstrate here that viral productivity and transmissibility but not viral cytotoxicity are drastically different among EV71 strains and can be associated with their epidemiological backgrounds. This is the first report demonstrating the dynamics of nonenveloped virus replication in cell culture using mathematical modeling.

Original languageEnglish
Pages (from-to)701-705
Number of pages5
JournalJournal of virology
Volume87
Issue number1
DOIs
Publication statusPublished - Jan 1 2013

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Enterovirus Infections
Enterovirus
hand, foot and mouth disease
Hand, Foot and Mouth Disease
infection
nervous system diseases
Virus Replication
virus replication
Nervous System Diseases
Disease Outbreaks
cytotoxicity
public health
cell culture
mathematical models
Public Health
Cell Culture Techniques

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Quantification of the dynamics of enterovirus 71 infection by experimental-mathematical investigation. / Fukuhara, Mitsuko; Iwami, Shingo; Sato, Kei; Nishimura, Yorihiro; Shimizu, Hiroyuki; Aihara, Kazuyuki; Koyanagi, Yoshio.

In: Journal of virology, Vol. 87, No. 1, 01.01.2013, p. 701-705.

Research output: Contribution to journalArticle

Fukuhara, M, Iwami, S, Sato, K, Nishimura, Y, Shimizu, H, Aihara, K & Koyanagi, Y 2013, 'Quantification of the dynamics of enterovirus 71 infection by experimental-mathematical investigation', Journal of virology, vol. 87, no. 1, pp. 701-705. https://doi.org/10.1128/JVI.01453-12
Fukuhara, Mitsuko ; Iwami, Shingo ; Sato, Kei ; Nishimura, Yorihiro ; Shimizu, Hiroyuki ; Aihara, Kazuyuki ; Koyanagi, Yoshio. / Quantification of the dynamics of enterovirus 71 infection by experimental-mathematical investigation. In: Journal of virology. 2013 ; Vol. 87, No. 1. pp. 701-705.
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