Quantitative image analyses of nuclear dynamics in migrating neurons

Hiroki Umeshima, Yuu Kure, Kenichi Nomura, Shuhei Yoshikawa, Shinya Sakuma, Fumihito Arai, Makoto Kaneko, Mineko Kengaku

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this paper, we present a novel method to investigate the mechanism driving nuclear translocation in migrating neurons via digital image analyses of the nucleus. We obtained and quantitatively analyzed time-lapse images of the fluorescently labeled nucleus with a high-speed confocal microscope. We focused on spatiotemporal dynamics of the boundary curvature of the nucleus during nuclear translocation. Our data suggest major contribution of a pulling force to nuclear translocation during neuronal migration.

Original languageEnglish
Title of host publication2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781479966790
DOIs
Publication statusPublished - Jan 9 2015
Externally publishedYes
Event2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014 - Nagoya, Japan
Duration: Nov 10 2014Nov 12 2014

Publication series

Name2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014

Other

Other2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014
CountryJapan
CityNagoya
Period11/10/1411/12/14

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering
  • Mechanical Engineering

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