Quantitative risk assessment of the first-hand/second-hand exposure occurred by vaping using computer simulated person integrated with virtual airway

Recently, the electric cigarette(e-cigarette) has been widely using in the world and prevention of exposure to hazardous chemical compounds generated from e-cigarette is an important issue. In this research, computer simulated person (CSP) that integrated with numerical respiratory tract model was developed for health risk assessment caused by e-cigarette usage. This paper treats the development of integrated numerical simulation method of physiologically-based pharma-cokinetic (PBPK) model and computational fluid dynamics (CFD) for estimating respiratory tract tissue dosimetry. Here, first-hand/second-hand exposure to e-cigarette smoke and its health impact were analyzed by using 2 CSPs which are assuming smoker and the other occupant.