TY - JOUR
T1 - Quantitative structure-activity studies of octopaminergic agonists and antagonists against Locusta migratoria using similarity indexes.
AU - Hirashima, A.
AU - Shinkai, K.
AU - Kuwano, E.
AU - Taniguchi, E.
AU - Eto, M.
N1 - Funding Information:
We thank Emeritus Prof. Toshio Fujita of Kyoto University and Tanabe Pharmacology Co. Japan for donating the QSAR program. We are grateful to Prof. Takaaki Sonoda of Institute of Advanced Material Study at Kyushu University in Japan for allowing us to use the CAChe Groupserver IBM RS6000. This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan.
PY - 2000
Y1 - 2000
N2 - The quantitative structure-activity relationship of 39 octopamine (OA) agonists and 12 antagonists against the thoracic nerve cord of the migratory locust, Locusta migratoria L. was analyzed using atom based rigid fit method or flexible fitting offered by PowerFit 1.0 from MicroSimulation. For OA agonists, the more similar to reference compound NC (24) the structure of test compound, the higher the activity, whereas for OA antagonists it was not the case. Antagonists may not interact with the same part of the membrane with which the agonists interact. Taken the part of the membrane with which the agonist interacts as the true receptor, the antagonist may well interact with an area surrounding the receptor including the ionophore.
AB - The quantitative structure-activity relationship of 39 octopamine (OA) agonists and 12 antagonists against the thoracic nerve cord of the migratory locust, Locusta migratoria L. was analyzed using atom based rigid fit method or flexible fitting offered by PowerFit 1.0 from MicroSimulation. For OA agonists, the more similar to reference compound NC (24) the structure of test compound, the higher the activity, whereas for OA antagonists it was not the case. Antagonists may not interact with the same part of the membrane with which the agonists interact. Taken the part of the membrane with which the agonist interacts as the true receptor, the antagonist may well interact with an area surrounding the receptor including the ionophore.
UR - http://www.scopus.com/inward/record.url?scp=0033643556&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033643556&partnerID=8YFLogxK
U2 - 10.1080/10629360008033228
DO - 10.1080/10629360008033228
M3 - Article
C2 - 10768405
AN - SCOPUS:0033643556
SN - 1062-936X
VL - 11
SP - 45
EP - 54
JO - SAR and QSAR in Environmental Research
JF - SAR and QSAR in Environmental Research
IS - 1
ER -