Quorum quenching strategy targeting gram-positive pathogenic bacteria

Ravindra Pal Singh, Said E. Desouky, Jiro Nakayama

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Citations (Scopus)

Abstract

Quorum sensing (QS) is a cell density-dependent regulatory system that orchestrates the group behavior of unicellular organisms by synchronizing the expression of certain gene(s) within the clonal community of same species. Bacterial pathogens often employ QS system to establish efficiently an infection. A large part of low GC Gram-positive bacteria belonging to phylum Firmicutes use thiolactone/lactone peptides as communication signals so-called autoinducing peptides (AIPs) to coordinate QS circuit. In particular, QS of staphylococci, enterococci, and clostridia have been intensively studied in terms of alternative target of antipathogenic chemotherapy independent of bactericidal antibiotics. Thus far, a number of quorum quenching (QQ) agents that targeting the QS circuit of these Gram-positive pathogens have been developed by random screening of natural compounds or rationale design of AIP antagonists. This review summarizes those QQ agents and previews their potential as post-antibiotic drugs.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
DOIs
Publication statusPublished - 2016

Publication series

NameAdvances in Experimental Medicine and Biology
Volume901
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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    Singh, R. P., Desouky, S. E., & Nakayama, J. (2016). Quorum quenching strategy targeting gram-positive pathogenic bacteria. In Advances in Experimental Medicine and Biology (Advances in Experimental Medicine and Biology; Vol. 901). Springer New York LLC. https://doi.org/10.1007/5584_2016_1