TY - JOUR
T1 - R(+)-8-OH-DPAT, a 5-HT(1A) receptor agonist, inhibits amphetamine-induced serotonin and dopamine release in rat medial prefrontal cortex
AU - Kuroki, Toshihide
AU - Ichikawa, Junji
AU - Dai, Jin
AU - Meltzer, Herbert Y.
N1 - Funding Information:
The research reported was supported in part by USPHS MH 41684, GCRC MO1RR00080 and the National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator Award grant as well as grants from Elisabeth Severance Prentiss Foundation and Mr. Larry Freedman. H.Y.M. is the recipient of a USPHS Research Career Scientist Award MH 47808. We are grateful to Mr. Yi-Qing Feng for a technical assistance.
PY - 1996
Y1 - 1996
N2 - Pretreatment with R(+)-8-OH-DPAT, a selective serotonin (5-HT)(1A) receptor agonist (50 μg/kg, s.c.), inhibited D-amphetamine sulfate (1.0 mg/kg, s.c.)-induced increases in extracellular levels of both 5-HT and dopamine (DA) in rat medial prefrontal cortex, as determined by in vivo microdialysis. The inhibitory effect of R(+)-8-OH-DPAT was completely reversed by the selective 5-HT(1A) receptor antagonist WAY 100,635 (100 μg/kg s.c.) administered 5 min prior to R(+)-8-OH-DPAT. These results suggest that stimulation of 5-HT(1A) receptors may inhibit amphetamine-induced release of 5-HT and DA in the medial prefrontal cortex.
AB - Pretreatment with R(+)-8-OH-DPAT, a selective serotonin (5-HT)(1A) receptor agonist (50 μg/kg, s.c.), inhibited D-amphetamine sulfate (1.0 mg/kg, s.c.)-induced increases in extracellular levels of both 5-HT and dopamine (DA) in rat medial prefrontal cortex, as determined by in vivo microdialysis. The inhibitory effect of R(+)-8-OH-DPAT was completely reversed by the selective 5-HT(1A) receptor antagonist WAY 100,635 (100 μg/kg s.c.) administered 5 min prior to R(+)-8-OH-DPAT. These results suggest that stimulation of 5-HT(1A) receptors may inhibit amphetamine-induced release of 5-HT and DA in the medial prefrontal cortex.
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U2 - 10.1016/S0006-8993(96)01111-0
DO - 10.1016/S0006-8993(96)01111-0
M3 - Article
C2 - 9017269
AN - SCOPUS:0030462454
SN - 0006-8993
VL - 743
SP - 357
EP - 361
JO - Molecular Brain Research
JF - Molecular Brain Research
IS - 1-2
ER -