R(+)-8-OH-DPAT, a 5-HT(1A) receptor agonist, inhibits amphetamine-induced serotonin and dopamine release in rat medial prefrontal cortex

Toshihide Kuroki, Junji Ichikawa, Jin Dai, Herbert Y. Meltzer

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Pretreatment with R(+)-8-OH-DPAT, a selective serotonin (5-HT)(1A) receptor agonist (50 μg/kg, s.c.), inhibited D-amphetamine sulfate (1.0 mg/kg, s.c.)-induced increases in extracellular levels of both 5-HT and dopamine (DA) in rat medial prefrontal cortex, as determined by in vivo microdialysis. The inhibitory effect of R(+)-8-OH-DPAT was completely reversed by the selective 5-HT(1A) receptor antagonist WAY 100,635 (100 μg/kg s.c.) administered 5 min prior to R(+)-8-OH-DPAT. These results suggest that stimulation of 5-HT(1A) receptors may inhibit amphetamine-induced release of 5-HT and DA in the medial prefrontal cortex.

Original languageEnglish
Pages (from-to)357-361
Number of pages5
JournalBrain Research
Issue number1-2
Publication statusPublished - Dec 1 1996


All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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