Radar chart deviation analysis of prion protein amino acid composition defines characteristic structural abnormalities of the N-terminal octapeptide tandem repeat

Satoru Yokotani, Takeru Nose, Yuji Horiuchi, Ayami Matsushima, Yasuyuki Shimohigashi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Analysis of the amino acid composition of prion protein using a newly developed program for radar-chart deviation analysis has identified an abnormality or irregularity of the N-terminal flexible domain. Aromatic amino acids Trp and His together with Gly are abnormally abounding in this Nterminal domain, in which octapeptide GQPHGGGW is connected four times in tandem. This tetrarepeat structure has been suggested to be essential for the prion protein not only to play an intrinsic functional role in the physiological condition, but also to bring on structural abnormalities in prion disease.

Original languageEnglish
Pages (from-to)949-955
Number of pages7
JournalProtein and Peptide Letters
Volume15
Issue number9
DOIs
Publication statusPublished - Sep 1 2008

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biochemistry

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