Radiation-induced osteosarcoma with a rhabdomyosarcoma component arising from the dura mater: A case report

S. Utsuki, H. Oka, K. Sato, S. Shimizu, Satoshi Suzuki, K. Fujii

Research output: Contribution to journalArticle

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Abstract

Objective: Radiation-induced tumors are a rare complication of radiation therapy. Here, we describe the first case of a radiation-induced osteosarcoma with a rhabdomyosarcoma component arising from the dura mater after radiation therapy for an astrocytoma. Patient: An 18-year-old man with generalized seizures presented with a neoplastic lesion in the dura mater of a previously irradiated (56 Gy) region 5 years after the initial radiation therapy. A tumor resection was performed, and histological examination revealed an osteosarcoma with a rhabdomyosarcoma component. The tumor recurred despite eight tumorectomies and the addition of chemotherapy and radiotherapy. The patient died from tumor progression 5 years after the first surgical removal of the radiation-induced tumor. Conclusion: This radiation-induced tumor may have originated from primitive, multipotent mesenchymal cells, as it included both osteosarcoma and rhabdomyosarcoma components.

Original languageEnglish
Pages (from-to)96-100
Number of pages5
JournalClinical Neuropathology
Volume28
Issue number2
Publication statusPublished - 2009
Externally publishedYes

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Dura Mater
Rhabdomyosarcoma
Osteosarcoma
Radiation
Radiotherapy
Neoplasms
Astrocytoma
Seizures
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neurology

Cite this

Radiation-induced osteosarcoma with a rhabdomyosarcoma component arising from the dura mater : A case report. / Utsuki, S.; Oka, H.; Sato, K.; Shimizu, S.; Suzuki, Satoshi; Fujii, K.

In: Clinical Neuropathology, Vol. 28, No. 2, 2009, p. 96-100.

Research output: Contribution to journalArticle

Utsuki, S. ; Oka, H. ; Sato, K. ; Shimizu, S. ; Suzuki, Satoshi ; Fujii, K. / Radiation-induced osteosarcoma with a rhabdomyosarcoma component arising from the dura mater : A case report. In: Clinical Neuropathology. 2009 ; Vol. 28, No. 2. pp. 96-100.
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