Radiation therapy for recurrent esophageal cancer after surgery: Clinical results and prognostic factors

Yoshiyuki Shioyama, Katsumasa Nakamura, Saiji Ohga, Satoshi Nomoto, Tomonari Sasaki, Toshihiro Yamaguchi, Takashi Toba, Tadamasa Yoshitake, Hiromi Terashima, Hiroshi Honda

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


Objective: To evaluate the outcome of radiotherapy for recurrent esophageal cancer after surgery and to determine the prognostic factors. Methods: From 1987 through 2002, 82 patients treated with radiotherapy for loco-regional recurrences of esophageal cancer after surgery were retrospectively reviewed. The stage at initial surgery was I in 16, II in 41, III or higher in 24 and unknown in 1. The median size of recurrent tumors was 3.5 cm in diameter. Fifty-two patients were treated with radiotherapy alone, and 30 were treated with radiotherapy combined with chemotherapy. The median total dose of external radiotherapy given was 50.4 Gy in 28 fractions. Results: The median survival period after recurrence was 7.0 months. The 2- and 5-year overall survival rate for all patients was 22 and 11%, respectively. In univariate analysis, the patients with performance status (PS) = 0-1, or tumor size <3.5 cm, and those treated with total dose ≥50 Gy showed a better survival outcome than each the other groups. The patients with a history of previous radiotherapy showed a poorer survival outcome in univariate analysis than each the other groups. In multivariate analysis, tumor size, PS and radiation dose were independent prognostic factors for overall survival. Conclusion: The prognosis of patients with post-operative loco-regional recurrence of esophageal cancer is poor. However, a long-term survival may be expected by definitive radiotherapy for the patients with small-size tumors and with a good PS.

Original languageEnglish
Pages (from-to)918-923
Number of pages6
JournalJapanese journal of clinical oncology
Issue number12
Publication statusPublished - Dec 2007

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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