Radioiodinated Nitroxide Derivative for the Detection of Lipid Radicals

Toshihide Yamasaki, Risa Azuma, Kohei Sano, Masayuki Munekane, Yuta Matsuoka, Ken Ichi Yamada, Takahiro Mukai

Research output: Contribution to journalArticle

Abstract

Thus far, no accurate measurement technology has been developed to detect lipid alkyl radicals (lipid radicals), which cause lipid peroxidation. Therefore, we aimed to develop a nuclear medical imaging probe that can be taken up in the lipophilic site in cells such as biological membranes, by reacting specifically with the lipid radicals generated there. We designed and synthesized 4-(4-[125I]iodobenzamido)-2,2,6,6-tetramethylpiperidine-1-oxyl, which shows high reactivity to lipid radicals with a high radiochemical yield and purity. Intracellular retention was found to increase significantly when lipid radicals were produced.

Original languageEnglish
Pages (from-to)45-48
Number of pages4
JournalACS Medicinal Chemistry Letters
Volume11
Issue number1
DOIs
Publication statusPublished - Jan 9 2020

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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