Radioiodinated Nitroxide Derivative for the Detection of Lipid Radicals

Toshihide Yamasaki; Risa Azuma; Kohei Sano; Masayuki Munekane; Yuta Matsuoka; Ken Ichi Yamada; Takahiro Mukai

doi:10.1021/acsmedchemlett.9b00416

Radioiodinated Nitroxide Derivative for the Detection of Lipid Radicals

Toshihide Yamasaki, Risa Azuma, Kohei Sano, Masayuki Munekane, Yuta Matsuoka, Ken Ichi Yamada, Takahiro Mukai

Molecular Bioinformatics

Research output: Contribution to journal › Article

Abstract

Thus far, no accurate measurement technology has been developed to detect lipid alkyl radicals (lipid radicals), which cause lipid peroxidation. Therefore, we aimed to develop a nuclear medical imaging probe that can be taken up in the lipophilic site in cells such as biological membranes, by reacting specifically with the lipid radicals generated there. We designed and synthesized 4-(4-[¹²⁵I]iodobenzamido)-2,2,6,6-tetramethylpiperidine-1-oxyl, which shows high reactivity to lipid radicals with a high radiochemical yield and purity. Intracellular retention was found to increase significantly when lipid radicals were produced.

Original language	English
Pages (from-to)	45-48
Number of pages	4
Journal	ACS Medicinal Chemistry Letters
Volume	11
Issue number	1
DOIs	https://doi.org/10.1021/acsmedchemlett.9b00416
Publication status	Published - Jan 9 2020

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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Yamasaki, T., Azuma, R., Sano, K., Munekane, M., Matsuoka, Y., Yamada, K. I., & Mukai, T. (2020). Radioiodinated Nitroxide Derivative for the Detection of Lipid Radicals. ACS Medicinal Chemistry Letters, 11(1), 45-48. https://doi.org/10.1021/acsmedchemlett.9b00416

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AU - Yamada, Ken Ichi

AU - Mukai, Takahiro

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