Radiological assessment of hepatic vein invasion by hepatocellular carcinoma using combined computed tomography hepatic arteriography and computed tomography arterial portography

Akihiro Nishie, Tsuyoshi Tajima, Yoshiki Asayama, Kosei Ishigami, Masakazu Hirakawa, yasuhiro ushijima, Daisuke Kakihara, Daisuke Okamoto, nobuhiro fujita, Akinobu Taketomi, Kengo Yoshimitsu, Hiroshi Honda

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Abstract

Purpose: The aim of this study was to elucidate computed tomography hepatic arteriography (CTHA) and CT arterial portography (CTAP) findings characteristic of hepatocellular carcinoma (HCC) with large hepatic venous invasion (HVI) and then to examine whether the presence of minute HVI can be diagnosed based on each finding. Materials and methods: Combined CTHA and CTAP of 106 HCCs were examined. Two radiologists analyzed the radiological findings of five nodules with large HVI (group vv2). The remaining 101 nodules were classified into two groups: group vv1, positive minute HVI; group vv0, negative HVI. They examined whether each finding observed in group vv2 could be detected in groups vv1 and vv0. Results: Analysis of group vv2 identified (a) tumor thrombus, (b) early inflow of the contrast into the hepatic vein proximal to the invaded site, and (c) partially decreased portal venous flow in the peripheral parenchyma subject to the involved hepatic vein. Findings (b) and (c) were observed in 16% of group vv1. A significant difference in frequency of finding (c) was obtained between groups vv1 and vv0. The positive and negative predictive values of finding (c) were 66.7% and 77.9%, respectively. Conclusion: Findings (b) and (c), especially the latter, may partly contribute to the radiological diagnosis of minute HVI.

Original languageEnglish
Pages (from-to)414-422
Number of pages9
JournalJapanese Journal of Radiology
Volume28
Issue number6
DOIs
Publication statusPublished - Jul 1 2010

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Portography
Hepatic Veins
Hepatocellular Carcinoma
Angiography
Tomography
Liver
Thrombosis

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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Radiological assessment of hepatic vein invasion by hepatocellular carcinoma using combined computed tomography hepatic arteriography and computed tomography arterial portography. / Nishie, Akihiro; Tajima, Tsuyoshi; Asayama, Yoshiki; Ishigami, Kosei; Hirakawa, Masakazu; ushijima, yasuhiro; Kakihara, Daisuke; Okamoto, Daisuke; fujita, nobuhiro; Taketomi, Akinobu; Yoshimitsu, Kengo; Honda, Hiroshi.

In: Japanese Journal of Radiology, Vol. 28, No. 6, 01.07.2010, p. 414-422.

Research output: Contribution to journalArticle

Nishie, Akihiro ; Tajima, Tsuyoshi ; Asayama, Yoshiki ; Ishigami, Kosei ; Hirakawa, Masakazu ; ushijima, yasuhiro ; Kakihara, Daisuke ; Okamoto, Daisuke ; fujita, nobuhiro ; Taketomi, Akinobu ; Yoshimitsu, Kengo ; Honda, Hiroshi. / Radiological assessment of hepatic vein invasion by hepatocellular carcinoma using combined computed tomography hepatic arteriography and computed tomography arterial portography. In: Japanese Journal of Radiology. 2010 ; Vol. 28, No. 6. pp. 414-422.
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T1 - Radiological assessment of hepatic vein invasion by hepatocellular carcinoma using combined computed tomography hepatic arteriography and computed tomography arterial portography

AU - Nishie, Akihiro

AU - Tajima, Tsuyoshi

AU - Asayama, Yoshiki

AU - Ishigami, Kosei

AU - Hirakawa, Masakazu

AU - ushijima, yasuhiro

AU - Kakihara, Daisuke

AU - Okamoto, Daisuke

AU - fujita, nobuhiro

AU - Taketomi, Akinobu

AU - Yoshimitsu, Kengo

AU - Honda, Hiroshi

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Y1 - 2010/7/1

N2 - Purpose: The aim of this study was to elucidate computed tomography hepatic arteriography (CTHA) and CT arterial portography (CTAP) findings characteristic of hepatocellular carcinoma (HCC) with large hepatic venous invasion (HVI) and then to examine whether the presence of minute HVI can be diagnosed based on each finding. Materials and methods: Combined CTHA and CTAP of 106 HCCs were examined. Two radiologists analyzed the radiological findings of five nodules with large HVI (group vv2). The remaining 101 nodules were classified into two groups: group vv1, positive minute HVI; group vv0, negative HVI. They examined whether each finding observed in group vv2 could be detected in groups vv1 and vv0. Results: Analysis of group vv2 identified (a) tumor thrombus, (b) early inflow of the contrast into the hepatic vein proximal to the invaded site, and (c) partially decreased portal venous flow in the peripheral parenchyma subject to the involved hepatic vein. Findings (b) and (c) were observed in 16% of group vv1. A significant difference in frequency of finding (c) was obtained between groups vv1 and vv0. The positive and negative predictive values of finding (c) were 66.7% and 77.9%, respectively. Conclusion: Findings (b) and (c), especially the latter, may partly contribute to the radiological diagnosis of minute HVI.

AB - Purpose: The aim of this study was to elucidate computed tomography hepatic arteriography (CTHA) and CT arterial portography (CTAP) findings characteristic of hepatocellular carcinoma (HCC) with large hepatic venous invasion (HVI) and then to examine whether the presence of minute HVI can be diagnosed based on each finding. Materials and methods: Combined CTHA and CTAP of 106 HCCs were examined. Two radiologists analyzed the radiological findings of five nodules with large HVI (group vv2). The remaining 101 nodules were classified into two groups: group vv1, positive minute HVI; group vv0, negative HVI. They examined whether each finding observed in group vv2 could be detected in groups vv1 and vv0. Results: Analysis of group vv2 identified (a) tumor thrombus, (b) early inflow of the contrast into the hepatic vein proximal to the invaded site, and (c) partially decreased portal venous flow in the peripheral parenchyma subject to the involved hepatic vein. Findings (b) and (c) were observed in 16% of group vv1. A significant difference in frequency of finding (c) was obtained between groups vv1 and vv0. The positive and negative predictive values of finding (c) were 66.7% and 77.9%, respectively. Conclusion: Findings (b) and (c), especially the latter, may partly contribute to the radiological diagnosis of minute HVI.

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