Radiotherapy for men with PSA failure following radical prostatectomy

Masaki Shiota, Hideya Noma, Akito Yamaguchi

Research output: Contribution to journalArticle

Abstract

We evaluated the efficacy of salvage external beam radiotherapy (RT) to the prostate bed for men with prostate-specific antigen (PSA) failure following radical prostatectomy. Fourteen patients underwent RT for PSA failure following radical prostatectomy between 1999 and 2000. Median follow-up was 24 months. Median PSA level before RT was 0.51 ng/ml. Radiation dose was 60Gy or 61.4Gy. The 3-year actuarial biochemical disease-free survival (bDFS) rate was 40%. The biochemical effectiveness of RT was better in cases with a PSA level of less than 1 ng/ml compared to that in cases with a level higher than 1 ng/ml. The PSA level before RT and surgical margin involvement were identified as prognostic factors for bDFS. No patients experienced grade 3 toxicity. RT for PSA failure following radical prostatectomy seems to be very effective and was only slightly toxic during a limited follow-up period.

Original languageEnglish
Pages (from-to)130-134
Number of pages5
JournalNishinihon Journal of Urology
Volume69
Issue number3
Publication statusPublished - Mar 1 2007
Externally publishedYes

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Prostate-Specific Antigen
Prostatectomy
Radiotherapy
Disease-Free Survival
Poisons
Prostate
Survival Rate
Radiation

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Radiotherapy for men with PSA failure following radical prostatectomy. / Shiota, Masaki; Noma, Hideya; Yamaguchi, Akito.

In: Nishinihon Journal of Urology, Vol. 69, No. 3, 01.03.2007, p. 130-134.

Research output: Contribution to journalArticle

Shiota, Masaki ; Noma, Hideya ; Yamaguchi, Akito. / Radiotherapy for men with PSA failure following radical prostatectomy. In: Nishinihon Journal of Urology. 2007 ; Vol. 69, No. 3. pp. 130-134.
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