Abstract
We evaluated the efficacy of salvage external beam radiotherapy (RT) to the prostate bed for men with prostate-specific antigen (PSA) failure following radical prostatectomy. Fourteen patients underwent RT for PSA failure following radical prostatectomy between 1999 and 2000. Median follow-up was 24 months. Median PSA level before RT was 0.51 ng/ml. Radiation dose was 60Gy or 61.4Gy. The 3-year actuarial biochemical disease-free survival (bDFS) rate was 40%. The biochemical effectiveness of RT was better in cases with a PSA level of less than 1 ng/ml compared to that in cases with a level higher than 1 ng/ml. The PSA level before RT and surgical margin involvement were identified as prognostic factors for bDFS. No patients experienced grade 3 toxicity. RT for PSA failure following radical prostatectomy seems to be very effective and was only slightly toxic during a limited follow-up period.
| Original language | English |
|---|---|
| Pages (from-to) | 130-134 |
| Number of pages | 5 |
| Journal | Nishinihon Journal of Urology |
| Volume | 69 |
| Issue number | 3 |
| Publication status | Published - Mar 1 2007 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Urology
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Radiotherapy for men with PSA failure following radical prostatectomy. / Shiota, Masaki; Noma, Hideya; Yamaguchi, Akito.
In: Nishinihon Journal of Urology, Vol. 69, No. 3, 01.03.2007, p. 130-134.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Radiotherapy for men with PSA failure following radical prostatectomy
AU - Shiota, Masaki
AU - Noma, Hideya
AU - Yamaguchi, Akito
PY - 2007/3/1
Y1 - 2007/3/1
N2 - We evaluated the efficacy of salvage external beam radiotherapy (RT) to the prostate bed for men with prostate-specific antigen (PSA) failure following radical prostatectomy. Fourteen patients underwent RT for PSA failure following radical prostatectomy between 1999 and 2000. Median follow-up was 24 months. Median PSA level before RT was 0.51 ng/ml. Radiation dose was 60Gy or 61.4Gy. The 3-year actuarial biochemical disease-free survival (bDFS) rate was 40%. The biochemical effectiveness of RT was better in cases with a PSA level of less than 1 ng/ml compared to that in cases with a level higher than 1 ng/ml. The PSA level before RT and surgical margin involvement were identified as prognostic factors for bDFS. No patients experienced grade 3 toxicity. RT for PSA failure following radical prostatectomy seems to be very effective and was only slightly toxic during a limited follow-up period.
AB - We evaluated the efficacy of salvage external beam radiotherapy (RT) to the prostate bed for men with prostate-specific antigen (PSA) failure following radical prostatectomy. Fourteen patients underwent RT for PSA failure following radical prostatectomy between 1999 and 2000. Median follow-up was 24 months. Median PSA level before RT was 0.51 ng/ml. Radiation dose was 60Gy or 61.4Gy. The 3-year actuarial biochemical disease-free survival (bDFS) rate was 40%. The biochemical effectiveness of RT was better in cases with a PSA level of less than 1 ng/ml compared to that in cases with a level higher than 1 ng/ml. The PSA level before RT and surgical margin involvement were identified as prognostic factors for bDFS. No patients experienced grade 3 toxicity. RT for PSA failure following radical prostatectomy seems to be very effective and was only slightly toxic during a limited follow-up period.
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M3 - Article
AN - SCOPUS:34247281108
VL - 69
SP - 130
EP - 134
JO - Nishinihon Journal of Urology
JF - Nishinihon Journal of Urology
SN - 0029-0726
IS - 3
ER -