Rapid and continuous accumulation of nitric oxide-releasing liposomes in tumors to augment the enhanced permeability and retention (EPR) effect

Takuma Yoshikawa, Yukina Mori, Haitao Feng, Khanh Quoc Phan, Akihiro Kishimura, Jeong Hun Kang, Takeshi Mori, Yoshiki Katayama

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

The modulation of blood flow to tumors is a prominent strategy for improving the tumor accumulation of nanomedicines, resulting from the enhanced permeability and retention (EPR) effect. We previously reported a promising EPR enhancer—a nitric oxide (NO) donor-containing liposome (NO-LP)—which showed enhanced accumulation in tumor tissue. Herein, we study NO-LP in greater detail to clarify its practical use as an EPR enhancer. NO-LP was found to have advantages as a NO donor, including the ability to maintain NO donation over long periods of time, and a constant rate of NO-release irrespective of the environmental pH. NO-LP showed rapid accumulation in tumor tissue after injection (1 h), and then accumulation was continuously enhanced until 48 h. Enhanced NO-LP accumulation was observed specifically in tumor, while the accumulation in other organs remained relatively unchanged. The results obtained show the promising features of NO-LP as an EPR enhancer.

Original languageEnglish
Pages (from-to)481-487
Number of pages7
JournalInternational Journal of Pharmaceutics
Volume565
DOIs
Publication statusPublished - Jun 30 2019

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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