Rapid increase in clusters of presynaptic proteins at onset of long-lasting potentiation

I. Antonova, O. Arancio, A. Trillat, H. Wang, L. Zablow, Hiroshi Udo, E. R. Kandel, R. D. Hawkins

Research output: Contribution to journalArticle

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Abstract

A change in the efficiency of synaptic communication between neurons is thought to underlie learning. Consistent with recent studies of such changes, we find that long-lasting potentiation of synaptic transmission between cultured hippocampal neurons is accompanied by an increase in the number of clusters of postsynaptic glutamate receptors containing the subunit GluR1. In addition, potentiation is accompanied by a rapid and long-lasting increase in the number of clusters of the presynaptic protein synaptophysin and the number of sites at which synaptophysin and GluR1 are colocalized. These results suggest that potentiation involves rapid coordinate changes in the distribution of proteins in the presynaptic neuron as well as the postsynaptic neuron.

Original languageEnglish
Pages (from-to)1547-1550
Number of pages4
JournalScience
Volume294
Issue number5546
DOIs
Publication statusPublished - Nov 16 2001

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Neurons
Synaptophysin
Proteins
Glutamate Receptors
Synaptic Transmission
Communication
Learning
Efficiency

All Science Journal Classification (ASJC) codes

  • General

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Antonova, I., Arancio, O., Trillat, A., Wang, H., Zablow, L., Udo, H., ... Hawkins, R. D. (2001). Rapid increase in clusters of presynaptic proteins at onset of long-lasting potentiation. Science, 294(5546), 1547-1550. https://doi.org/10.1126/science.1066273

Rapid increase in clusters of presynaptic proteins at onset of long-lasting potentiation. / Antonova, I.; Arancio, O.; Trillat, A.; Wang, H.; Zablow, L.; Udo, Hiroshi; Kandel, E. R.; Hawkins, R. D.

In: Science, Vol. 294, No. 5546, 16.11.2001, p. 1547-1550.

Research output: Contribution to journalArticle

Antonova, I, Arancio, O, Trillat, A, Wang, H, Zablow, L, Udo, H, Kandel, ER & Hawkins, RD 2001, 'Rapid increase in clusters of presynaptic proteins at onset of long-lasting potentiation', Science, vol. 294, no. 5546, pp. 1547-1550. https://doi.org/10.1126/science.1066273
Antonova I, Arancio O, Trillat A, Wang H, Zablow L, Udo H et al. Rapid increase in clusters of presynaptic proteins at onset of long-lasting potentiation. Science. 2001 Nov 16;294(5546):1547-1550. https://doi.org/10.1126/science.1066273
Antonova, I. ; Arancio, O. ; Trillat, A. ; Wang, H. ; Zablow, L. ; Udo, Hiroshi ; Kandel, E. R. ; Hawkins, R. D. / Rapid increase in clusters of presynaptic proteins at onset of long-lasting potentiation. In: Science. 2001 ; Vol. 294, No. 5546. pp. 1547-1550.
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