Rapid Naked-Eye Discrimination of Cytochrome P450 Genetic Polymorphism through Non-Crosslinking Aggregation of DNA-Functionalized Gold Nanoparticles

Yoshitsugu Akiyama, Guoqing Wang, Shota Shiraishi, Naoki Kanayama, Tohru Takarada, Mizuo Maeda

Research output: Contribution to journalComment/debate

Abstract

The front cover artwork is provided by the group of Tohru Takarada at RIKEN (Japan). The image shows a colorimetric single-nucleotide polymorphism (SNP) genotyping method that uses spontaneous aggregation of DNA-modified gold nanoparticles (DNA–AuNPs) for the simple and rapid SNP genotyping of the human cytochrome P450 2C19 monooxygenase gene. For more details, read the full text of the Full Paper at p. 508.

Original languageEnglish
Number of pages1
JournalChemistryOpen
Volume5
Issue number6
DOIs
Publication statusPublished - Dec 1 2016
Externally publishedYes

Fingerprint

Polymorphism
Gold
Cytochrome P-450 Enzyme System
Agglomeration
Nucleotides
Nanoparticles
DNA
Mixed Function Oxygenases
Genes
human CYP2C19 protein

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Rapid Naked-Eye Discrimination of Cytochrome P450 Genetic Polymorphism through Non-Crosslinking Aggregation of DNA-Functionalized Gold Nanoparticles. / Akiyama, Yoshitsugu; Wang, Guoqing; Shiraishi, Shota; Kanayama, Naoki; Takarada, Tohru; Maeda, Mizuo.

In: ChemistryOpen, Vol. 5, No. 6, 01.12.2016.

Research output: Contribution to journalComment/debate

Akiyama, Yoshitsugu ; Wang, Guoqing ; Shiraishi, Shota ; Kanayama, Naoki ; Takarada, Tohru ; Maeda, Mizuo. / Rapid Naked-Eye Discrimination of Cytochrome P450 Genetic Polymorphism through Non-Crosslinking Aggregation of DNA-Functionalized Gold Nanoparticles. In: ChemistryOpen. 2016 ; Vol. 5, No. 6.
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