Rapid Normalization of Portopulmonary Hypertension After Living Donor Liver Transplantation

K. Sugimachi, Y. Soejima, K. Morita, S. Ueda, T. Fukuhara, S. Nagata, T. Ikegami, A. Taketomi, Y. Maehara

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Abstract

Portopulmonary hypertension (PPHTN) is a relatively rare complication of end-stage liver disease, and a serious problem in the context of liver transplantation. Herein we have reported a case of decompensated liver cirrhosis with PPHTN, which rapidly resolved after adult-to-adult living donor liver transplantation (LDLT). A 54-year-old man was referred to our hospital with end-stage liver cirrhosis owing to chronic hepatitis C. Preoperative mean pulmonary artery pressure (mPAP), as assessed by right heart catheterization, was 38 mm Hg. Continuous infusion of epoprostenol decreased the mPAP to 24 mm Hg over 44 days. He underwent LDLT using a right hepatic lobe graft donated by his son. The postoperative course was uneventful, epoprostenol was weaned by postoperative day (POD) 21, and the mPAP normalized to 21 mm Hg on POD 28. The patient was discharged on POD 31 without any vasodilators. Our case revealed that liver transplantation can rapidly resolve PPTHN.

Original languageEnglish
Pages (from-to)1976-1978
Number of pages3
JournalTransplantation Proceedings
Volume41
Issue number5
DOIs
Publication statusPublished - Jun 1 2009

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Living Donors
Liver Transplantation
Pulmonary Artery
Hypertension
Epoprostenol
Pressure
Liver Cirrhosis
End Stage Liver Disease
Chronic Hepatitis C
Cardiac Catheterization
Nuclear Family
Vasodilator Agents
Transplants
Liver

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

Cite this

Sugimachi, K., Soejima, Y., Morita, K., Ueda, S., Fukuhara, T., Nagata, S., ... Maehara, Y. (2009). Rapid Normalization of Portopulmonary Hypertension After Living Donor Liver Transplantation. Transplantation Proceedings, 41(5), 1976-1978. https://doi.org/10.1016/j.transproceed.2009.02.095

Rapid Normalization of Portopulmonary Hypertension After Living Donor Liver Transplantation. / Sugimachi, K.; Soejima, Y.; Morita, K.; Ueda, S.; Fukuhara, T.; Nagata, S.; Ikegami, T.; Taketomi, A.; Maehara, Y.

In: Transplantation Proceedings, Vol. 41, No. 5, 01.06.2009, p. 1976-1978.

Research output: Contribution to journalArticle

Sugimachi, K, Soejima, Y, Morita, K, Ueda, S, Fukuhara, T, Nagata, S, Ikegami, T, Taketomi, A & Maehara, Y 2009, 'Rapid Normalization of Portopulmonary Hypertension After Living Donor Liver Transplantation', Transplantation Proceedings, vol. 41, no. 5, pp. 1976-1978. https://doi.org/10.1016/j.transproceed.2009.02.095
Sugimachi, K. ; Soejima, Y. ; Morita, K. ; Ueda, S. ; Fukuhara, T. ; Nagata, S. ; Ikegami, T. ; Taketomi, A. ; Maehara, Y. / Rapid Normalization of Portopulmonary Hypertension After Living Donor Liver Transplantation. In: Transplantation Proceedings. 2009 ; Vol. 41, No. 5. pp. 1976-1978.
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