Rapid production of pancreatic carcinoma by initiation with N-Nitroso-bis(2-oxopropyl)amine and repeated augmentation pressure in hamsters

Kazuhiro Mizumoto, Masahiro Tsutsumi, Ayumi Denda, Yoichi Konishi

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58 Citations (Scopus)

Abstract

A rapid-production model incorporating the principle of selection by resistance to cytotoxicity demonstrated earlier for liver carcinogenesis in rats was established for pancreatic carcinoma development in Syrian hamsters. Adenocarcinomas were induced in 84% of treated animals by 10 weeks after initiation with 70 mg of N-nitroso-bis(2-oxopropyl)amine (BOP) per kg of body weight when augmentation pressure (choline-deficient diet combined with DL-ethionine and L-methionine and administration of 20 mg/kg BOP upon return to basal diet) was applied three times. A 52% yield of cholanglocellular tumors also resulted from this experimental protocol. [J Natl Cancer Inst 1988;80:1564-1567]

Original languageEnglish
Pages (from-to)1564-1567
Number of pages4
JournalJournal of the National Cancer Institute
Volume80
Issue number19
DOIs
Publication statusPublished - Jul 7 1988

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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