TY - JOUR
T1 - Rapid progress of DNA replication studies in Archaea, the third domain of life
AU - Ishino, Yoshizumi
AU - Ishino, Sonoko
N1 - Funding Information:
Our work cited in this review was supported in part by the Human Frontier Science Program, several research grants from Ministry of Education, Culture, Sports, Science, and Technology of Japan, the Japan New Energy and Industrial Technology Development Organization, and the Japan Science and Technology Agency. We apologize to the researchers whose work was not cited because of space limitations.
PY - 2012/5
Y1 - 2012/5
N2 - Archaea, the third domain of life, are interesting organisms to study from the aspects of molecular and evolutionary biology. Archaeal cells have a unicellular ultrastructure without a nucleus, resembling bacterial cells, but the proteins involved in genetic information processing pathways, including DNA replication, transcription, and translation, share strong similarities with those of Eukaryota. Therefore, archaea provide useful model systems to understand the more complex mechanisms of genetic information processing in eukaryotic cells. Moreover, the hyperthermophilic archaea provide very stable proteins, which are especially useful for the isolation of replisomal multicomplexes, to analyze their structures and functions. This review focuses on the history, current status, and future directions of archaeal DNA replication studies.
AB - Archaea, the third domain of life, are interesting organisms to study from the aspects of molecular and evolutionary biology. Archaeal cells have a unicellular ultrastructure without a nucleus, resembling bacterial cells, but the proteins involved in genetic information processing pathways, including DNA replication, transcription, and translation, share strong similarities with those of Eukaryota. Therefore, archaea provide useful model systems to understand the more complex mechanisms of genetic information processing in eukaryotic cells. Moreover, the hyperthermophilic archaea provide very stable proteins, which are especially useful for the isolation of replisomal multicomplexes, to analyze their structures and functions. This review focuses on the history, current status, and future directions of archaeal DNA replication studies.
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U2 - 10.1007/s11427-012-4324-9
DO - 10.1007/s11427-012-4324-9
M3 - Review article
C2 - 22645083
AN - SCOPUS:84861692094
SN - 1674-7305
VL - 55
SP - 386
EP - 403
JO - Science China Life Sciences
JF - Science China Life Sciences
IS - 5
ER -