Rapid progression of vascular and soft tissue calcification while being managed for severe and persistent hypocalcemia induced by denosumab treatment in a patient with multiple myeloma and chronic kidney disease

Kenji Ueki, Shunsuke Yamada, Akihiro Tsuchimoto, Masanori Tokumoto, Takashi Kumano, Takanari Kitazono, Kazuhiko Tsuruya

Research output: Contribution to journalArticle

3 Citations (Scopus)


We herein present the case of a patient with myeloma and chronic kidney disease (CKD) who developed rapidly progressive vascular and soft tissue calcification during the course of treatment for severe hypocalcemia induced by the administration of denosumab for myeloma and hypercalcemia. Because a large amount of supplementation with active vitamin D and calcium was required to correct the severe hypocalcemia, rapidly progressive vascular calcification developed. Seeing that patients with CKD are prone to developing severe and prolonged hypocalcemia after denosumab treatment, physicians should closely monitor the patients’ serum calcium levels and manage their hypocalcemia appropriately so as to avoid the development of significant ectopic calcification.

Original languageEnglish
Pages (from-to)2637-2642
Number of pages6
JournalInternal Medicine
Issue number20
Publication statusPublished - Oct 15 2015


All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this