Rapid structural analysis of nanomaterials in aqueous solutions

Sou Ryuzaki, Makusu Tsutsui, Yuhui He, Kazumichi Yokota, Akihide Arima, Takanori Morikawa, Masateru Taniguchi, Tomoji Kawai

Research output: Contribution to journalArticle

5 Citations (Scopus)


Rapid structural analysis of nanoscale matter in a liquid environment represents innovative technologies that reveal the identities and functions of biologically important molecules. However, there is currently no method with high spatio-temporal resolution that can scan individual particles in solutions to gain structural information. Here we report the development of a nanopore platform realizing quantitative structural analysis for suspended nanomaterials in solutions with a high z-axis and xy-plane spatial resolution of 35.8 ±1.1 and 12 nm, respectively. We used a low thickness-to-diameter aspect ratio pore architecture for achieving cross sectional areas of analyte (i.e. tomograms). Combining this with multiphysics simulation methods to translate ionic current data into tomograms, we demonstrated rapid structural analysis of single polystyrene (Pst) beads and single dumbbell-like Pst beads in aqueous solutions.

Original languageEnglish
Article number155501
Issue number15
Publication statusPublished - Mar 17 2017


All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering

Cite this

Ryuzaki, S., Tsutsui, M., He, Y., Yokota, K., Arima, A., Morikawa, T., ... Kawai, T. (2017). Rapid structural analysis of nanomaterials in aqueous solutions. Nanotechnology, 28(15), [155501]. https://doi.org/10.1088/1361-6528/aa5e66