Rapid virological response obtained by natural IFN α for a patient of chronic hepatitis C with a high viral load of HCV genotype 1b who is refractory to peg-interferon α+ ribavirin combination therapy

Akira Kawano, Yuichiro Kado, Hirohisa Shigematsu, Koichiro Miki, Toshihiro Maruyama, Hideyuki Nomura, Shinji Shimoda

Research output: Contribution to journalArticle

Abstract

Interferon monotherapy is considered to have limited effectiveness in patients with HCV of a high viral load. Here, we reported a 21-year old male of chronic hepatitis C with a high viral load of HCV genotype 1b. He received both peg-interferon α-2b plus ribavirin and peg-interferon α-2a plus ribavirin combination therapy. But there were no virological response Nevertheless, after starting natural interferon α (human lymphoblastoid interferon (HLBI), Sumiferon; Dainippon Sumitomo Pharmaceutical Co., Osaka, Japan), he became HCV-RNA negative at 4 week. The therapy is continued and HCV-RNA negativity is sustained for over 40 weeks. Eradication of HCV might be expected. Natural IFN α contains more than 20 subtypes, and one or more of them may have therapeutic effect against HCV virus of this patient.

Original languageEnglish
Pages (from-to)590-592
Number of pages3
JournalActa Hepatologica Japonica
Volume50
Issue number10
DOIs
Publication statusPublished - Dec 1 2009

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All Science Journal Classification (ASJC) codes

  • Hepatology

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