TY - JOUR
T1 - Rapidly growing hepatocellular carcinoma recurrence during direct-acting antiviral treatment for chronic hepatitis C
AU - Yamashita, Nobuyuki
AU - Tanimoto, Hironori
AU - Shimoda, Shinji
AU - Komori, Atsumasa
AU - Nomura, Hideyuki
N1 - Funding Information:
We thank Assoc. Prof. Hidetaka Yamamoto of the Department of Anatomic Pathology, Pathological Science, Graduate School of Medical Sciences, Kyushu University (Fukuoka, Japan), for his pathological diagnosis, and Prof. Shinichi Aishima of the Departments of Pathology and Microbiology, Saga University Faculty of Medicine (Saga, Japan), for his advice. All authors declare no conflict of interest.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - We herein report the case of a woman in her 80s with a recurrent hepatocellular carcinoma (HCC) tumor that rapidly increased in size during direct-acting antiviral (DAA) treatment. She suffered from HCC at her initial visit to our department and underwent hepatectomy. Thereafter, she underwent DAA treatment for chronic hepatitis C; however, her alpha-fetoprotein (AFP) level rapidly increased, and a liver tumor of > 1 cm in diameter was observed that had not been seen immediately before DAA treatment. She underwent hepatectomy again and moderate to poorly differentiated HCC was diagnosed. The patient’s AFP level showed a rapid increase immediately after the start of DAA treatment; however, the increase ceased after the first month, and the influence from the surrounding environment of the tumor was considered to be temporary.
AB - We herein report the case of a woman in her 80s with a recurrent hepatocellular carcinoma (HCC) tumor that rapidly increased in size during direct-acting antiviral (DAA) treatment. She suffered from HCC at her initial visit to our department and underwent hepatectomy. Thereafter, she underwent DAA treatment for chronic hepatitis C; however, her alpha-fetoprotein (AFP) level rapidly increased, and a liver tumor of > 1 cm in diameter was observed that had not been seen immediately before DAA treatment. She underwent hepatectomy again and moderate to poorly differentiated HCC was diagnosed. The patient’s AFP level showed a rapid increase immediately after the start of DAA treatment; however, the increase ceased after the first month, and the influence from the surrounding environment of the tumor was considered to be temporary.
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U2 - 10.1007/s12328-018-0876-y
DO - 10.1007/s12328-018-0876-y
M3 - Article
C2 - 29948818
AN - SCOPUS:85048362670
SN - 1865-7257
VL - 11
SP - 497
EP - 500
JO - Clinical Journal of Gastroenterology
JF - Clinical Journal of Gastroenterology
IS - 6
ER -
