Rapidly growing hepatocellular carcinoma recurrence during direct-acting antiviral treatment for chronic hepatitis C

Nobuyuki Yamashita, Hironori Tanimoto, Shinji Shimoda, Atsumasa Komori, Hideyuki Nomura

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2 Citations (Scopus)


We herein report the case of a woman in her 80s with a recurrent hepatocellular carcinoma (HCC) tumor that rapidly increased in size during direct-acting antiviral (DAA) treatment. She suffered from HCC at her initial visit to our department and underwent hepatectomy. Thereafter, she underwent DAA treatment for chronic hepatitis C; however, her alpha-fetoprotein (AFP) level rapidly increased, and a liver tumor of > 1 cm in diameter was observed that had not been seen immediately before DAA treatment. She underwent hepatectomy again and moderate to poorly differentiated HCC was diagnosed. The patient’s AFP level showed a rapid increase immediately after the start of DAA treatment; however, the increase ceased after the first month, and the influence from the surrounding environment of the tumor was considered to be temporary.

Original languageEnglish
Pages (from-to)497-500
Number of pages4
JournalClinical Journal of Gastroenterology
Issue number6
Publication statusPublished - Dec 1 2018


All Science Journal Classification (ASJC) codes

  • Gastroenterology

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