Rapidly progressive heart failure in a female carrier of Becker muscular dystrophy with no skeletal muscle symptoms

Hirokazu Komoriyama, Arata Fukushima, Yumi Takahashi, Shintaro Kinugawa, Fusako Sera, Tomohito Ohtani, Akinori Nakamura, Yasushi Sakata, Toshihisa Anzai

Research output: Contribution to journalArticle

Abstract

Becker muscular dystrophy (BMD) carriers are at risk to developing cardiac dysfunction. The prevalence of female BMD carriers remains underestimated, and the disease progression varies. We herein report the case of a young female BMD carrier who developed dilated cardiomyopathy (DCM) and heart failure without any skeletal muscle signs. Her cardiac dysfunction progressed over a mere two months, resulting in the need for left ventricular assist device implantation. Her case demonstrates that progressive cardiomyopathy can be the only clinical manifestation in some BMD carriers, suggesting the need for a more aggressive implementation of genetic testing in female DCM patients.

Original languageEnglish
Pages (from-to)2545-2549
Number of pages5
JournalInternal Medicine
Volume58
Issue number17
DOIs
Publication statusPublished - Jan 1 2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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  • Cite this

    Komoriyama, H., Fukushima, A., Takahashi, Y., Kinugawa, S., Sera, F., Ohtani, T., Nakamura, A., Sakata, Y., & Anzai, T. (2019). Rapidly progressive heart failure in a female carrier of Becker muscular dystrophy with no skeletal muscle symptoms. Internal Medicine, 58(17), 2545-2549. https://doi.org/10.2169/internalmedicine.2714-19