Rare fetal complications associated with placental mesenchymal dysplasia: A report of two cases

Tomoka Jimbo, Yasuyuki Fujita, Yasuo Yumoto, Kotaro Fukushima, Kiyoko Kato

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Placental mesenchymal dysplasia (PMD) is a rare disease that may be difficult to distinguish from molar pregnancy. The disease is associated with major fetal complications, including Beckwith-Wiedemann syndrome, fetal growth restriction and intrauterine fetal death. Rarely, fetal hematological disorders and liver tumors also may occur. Two patients were referred to our hospital during their second trimesters because of suspected molar pregnancies. Fetal karyotyping and maternal serum human chorionic gonadotropin level determinations led to the PMD diagnoses. In one case, the maternal clinical course was normal, but the neonate suffered from disseminated intravascular coagulation and needed a platelet transfusion. In the second case, the PMD decreased during pregnancy, but a gradually increasing fetal liver tumor appeared. The tumor was diagnosed as mesenchymal hamartoma, based on ultrasound and magnetic resonance imaging studies. The neonate was delivered without cardiovascular compromise. Due to the difficulty of immediate surgical treatment, expectant management, with close follow-up, was chosen.

Original languageEnglish
Pages (from-to)304-308
Number of pages5
JournalJournal of Obstetrics and Gynaecology Research
Volume41
Issue number2
DOIs
Publication statusPublished - Feb 1 2015

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Hydatidiform Mole
Mothers
Beckwith-Wiedemann Syndrome
Newborn Infant
Karyotyping
Neoplasms
Platelet Transfusion
Fetal Death
Hamartoma
Disseminated Intravascular Coagulation
Liver
Second Pregnancy Trimester
Chorionic Gonadotropin
Rare Diseases
Fetal Development
Magnetic Resonance Imaging
Pregnancy
Serum
Therapeutics

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

Rare fetal complications associated with placental mesenchymal dysplasia : A report of two cases. / Jimbo, Tomoka; Fujita, Yasuyuki; Yumoto, Yasuo; Fukushima, Kotaro; Kato, Kiyoko.

In: Journal of Obstetrics and Gynaecology Research, Vol. 41, No. 2, 01.02.2015, p. 304-308.

Research output: Contribution to journalArticle

Jimbo, Tomoka ; Fujita, Yasuyuki ; Yumoto, Yasuo ; Fukushima, Kotaro ; Kato, Kiyoko. / Rare fetal complications associated with placental mesenchymal dysplasia : A report of two cases. In: Journal of Obstetrics and Gynaecology Research. 2015 ; Vol. 41, No. 2. pp. 304-308.
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