Ratio of serum n-3 to n-6 polyunsaturated fatty acids and the incidence of major adverse cardiac events in patients undergoing percutaneous coronary intervention

Takenori Domei, Hiroyoshi Yokoi, Shoichi Kuramitsu, Yoshimitsu Soga, Takeshi Arita, Kenji Ando, Shinichi Shirai, Katsuhiro Kondo, Koyu Sakai, Masahiko Goya, Masashi Iwabuchi, Masayuki Ueeda, Masakiyo Nobuyoshi

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Background: The relationship between major adverse cardiac events (MACE) and serum polyunsaturated fatty acid (PUFA) parameters has not been well documented in patients who have undergone percutaneous coronary intervention (PCI). The aim of the present study was to investigate this relationship. Methods and Results: A total of 284 consecutive patients who underwent elective PCI were enrolled and stratified according to median serum levels of n-6 PUFAs (arachidonic acid [AA]), n-3 PUFAs (eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]), and serum EPA/AA and DHA/AA ratios. The relationship between these PUFA parameters and the incidence of MACE including cardiac death, acute coronary syndrome, PCI for de novo lesions, and coronary artery bypass grafting, was analyzed. Multivariate analysis showed that among the PUFA parameters, only a high serum EPA/AA ratio was significantly associated with a low incidence of MACE in all the models tested (model A, without adjusted variables: hazard ratio [HR], 0.52; 95% confidence interval [CI]: 0.27-0.99, P=0.048; model B, adjusted for age and diabetes: HR, 0.51; 95%CI: 0.26-0.98, P=0.043; model C, adjusted for age, sex, diabetes, hypertension, smoking, and low-density lipoprotein cholesterol: HR, 0.49; 95%CI: 0.25-0.94, P=0.033). Conclusions: The incidence of MACE in patients who have undergone PCI is significantly associated with serum EPA/AA ratio.

Original languageEnglish
Pages (from-to)423-429
Number of pages7
JournalCirculation Journal
Volume76
Issue number2
DOIs
Publication statusPublished - Jan 31 2012
Externally publishedYes

Fingerprint

Percutaneous Coronary Intervention
Unsaturated Fatty Acids
Arachidonic Acid
Eicosapentaenoic Acid
Incidence
Serum
Docosahexaenoic Acids
Confidence Intervals
Omega-3 Fatty Acids
Acute Coronary Syndrome
Coronary Artery Bypass
LDL Cholesterol
Multivariate Analysis
Smoking
Hypertension

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Ratio of serum n-3 to n-6 polyunsaturated fatty acids and the incidence of major adverse cardiac events in patients undergoing percutaneous coronary intervention. / Domei, Takenori; Yokoi, Hiroyoshi; Kuramitsu, Shoichi; Soga, Yoshimitsu; Arita, Takeshi; Ando, Kenji; Shirai, Shinichi; Kondo, Katsuhiro; Sakai, Koyu; Goya, Masahiko; Iwabuchi, Masashi; Ueeda, Masayuki; Nobuyoshi, Masakiyo.

In: Circulation Journal, Vol. 76, No. 2, 31.01.2012, p. 423-429.

Research output: Contribution to journalArticle

Domei, T, Yokoi, H, Kuramitsu, S, Soga, Y, Arita, T, Ando, K, Shirai, S, Kondo, K, Sakai, K, Goya, M, Iwabuchi, M, Ueeda, M & Nobuyoshi, M 2012, 'Ratio of serum n-3 to n-6 polyunsaturated fatty acids and the incidence of major adverse cardiac events in patients undergoing percutaneous coronary intervention', Circulation Journal, vol. 76, no. 2, pp. 423-429. https://doi.org/10.1253/circj.CJ-11-0941
Domei, Takenori ; Yokoi, Hiroyoshi ; Kuramitsu, Shoichi ; Soga, Yoshimitsu ; Arita, Takeshi ; Ando, Kenji ; Shirai, Shinichi ; Kondo, Katsuhiro ; Sakai, Koyu ; Goya, Masahiko ; Iwabuchi, Masashi ; Ueeda, Masayuki ; Nobuyoshi, Masakiyo. / Ratio of serum n-3 to n-6 polyunsaturated fatty acids and the incidence of major adverse cardiac events in patients undergoing percutaneous coronary intervention. In: Circulation Journal. 2012 ; Vol. 76, No. 2. pp. 423-429.
@article{e9b3128903874f2793c3a178281fccc1,
title = "Ratio of serum n-3 to n-6 polyunsaturated fatty acids and the incidence of major adverse cardiac events in patients undergoing percutaneous coronary intervention",
abstract = "Background: The relationship between major adverse cardiac events (MACE) and serum polyunsaturated fatty acid (PUFA) parameters has not been well documented in patients who have undergone percutaneous coronary intervention (PCI). The aim of the present study was to investigate this relationship. Methods and Results: A total of 284 consecutive patients who underwent elective PCI were enrolled and stratified according to median serum levels of n-6 PUFAs (arachidonic acid [AA]), n-3 PUFAs (eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]), and serum EPA/AA and DHA/AA ratios. The relationship between these PUFA parameters and the incidence of MACE including cardiac death, acute coronary syndrome, PCI for de novo lesions, and coronary artery bypass grafting, was analyzed. Multivariate analysis showed that among the PUFA parameters, only a high serum EPA/AA ratio was significantly associated with a low incidence of MACE in all the models tested (model A, without adjusted variables: hazard ratio [HR], 0.52; 95{\%} confidence interval [CI]: 0.27-0.99, P=0.048; model B, adjusted for age and diabetes: HR, 0.51; 95{\%}CI: 0.26-0.98, P=0.043; model C, adjusted for age, sex, diabetes, hypertension, smoking, and low-density lipoprotein cholesterol: HR, 0.49; 95{\%}CI: 0.25-0.94, P=0.033). Conclusions: The incidence of MACE in patients who have undergone PCI is significantly associated with serum EPA/AA ratio.",
author = "Takenori Domei and Hiroyoshi Yokoi and Shoichi Kuramitsu and Yoshimitsu Soga and Takeshi Arita and Kenji Ando and Shinichi Shirai and Katsuhiro Kondo and Koyu Sakai and Masahiko Goya and Masashi Iwabuchi and Masayuki Ueeda and Masakiyo Nobuyoshi",
year = "2012",
month = "1",
day = "31",
doi = "10.1253/circj.CJ-11-0941",
language = "English",
volume = "76",
pages = "423--429",
journal = "Circulation Journal",
issn = "1346-9843",
publisher = "Japanese Circulation Society",
number = "2",

}

TY - JOUR

T1 - Ratio of serum n-3 to n-6 polyunsaturated fatty acids and the incidence of major adverse cardiac events in patients undergoing percutaneous coronary intervention

AU - Domei, Takenori

AU - Yokoi, Hiroyoshi

AU - Kuramitsu, Shoichi

AU - Soga, Yoshimitsu

AU - Arita, Takeshi

AU - Ando, Kenji

AU - Shirai, Shinichi

AU - Kondo, Katsuhiro

AU - Sakai, Koyu

AU - Goya, Masahiko

AU - Iwabuchi, Masashi

AU - Ueeda, Masayuki

AU - Nobuyoshi, Masakiyo

PY - 2012/1/31

Y1 - 2012/1/31

N2 - Background: The relationship between major adverse cardiac events (MACE) and serum polyunsaturated fatty acid (PUFA) parameters has not been well documented in patients who have undergone percutaneous coronary intervention (PCI). The aim of the present study was to investigate this relationship. Methods and Results: A total of 284 consecutive patients who underwent elective PCI were enrolled and stratified according to median serum levels of n-6 PUFAs (arachidonic acid [AA]), n-3 PUFAs (eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]), and serum EPA/AA and DHA/AA ratios. The relationship between these PUFA parameters and the incidence of MACE including cardiac death, acute coronary syndrome, PCI for de novo lesions, and coronary artery bypass grafting, was analyzed. Multivariate analysis showed that among the PUFA parameters, only a high serum EPA/AA ratio was significantly associated with a low incidence of MACE in all the models tested (model A, without adjusted variables: hazard ratio [HR], 0.52; 95% confidence interval [CI]: 0.27-0.99, P=0.048; model B, adjusted for age and diabetes: HR, 0.51; 95%CI: 0.26-0.98, P=0.043; model C, adjusted for age, sex, diabetes, hypertension, smoking, and low-density lipoprotein cholesterol: HR, 0.49; 95%CI: 0.25-0.94, P=0.033). Conclusions: The incidence of MACE in patients who have undergone PCI is significantly associated with serum EPA/AA ratio.

AB - Background: The relationship between major adverse cardiac events (MACE) and serum polyunsaturated fatty acid (PUFA) parameters has not been well documented in patients who have undergone percutaneous coronary intervention (PCI). The aim of the present study was to investigate this relationship. Methods and Results: A total of 284 consecutive patients who underwent elective PCI were enrolled and stratified according to median serum levels of n-6 PUFAs (arachidonic acid [AA]), n-3 PUFAs (eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]), and serum EPA/AA and DHA/AA ratios. The relationship between these PUFA parameters and the incidence of MACE including cardiac death, acute coronary syndrome, PCI for de novo lesions, and coronary artery bypass grafting, was analyzed. Multivariate analysis showed that among the PUFA parameters, only a high serum EPA/AA ratio was significantly associated with a low incidence of MACE in all the models tested (model A, without adjusted variables: hazard ratio [HR], 0.52; 95% confidence interval [CI]: 0.27-0.99, P=0.048; model B, adjusted for age and diabetes: HR, 0.51; 95%CI: 0.26-0.98, P=0.043; model C, adjusted for age, sex, diabetes, hypertension, smoking, and low-density lipoprotein cholesterol: HR, 0.49; 95%CI: 0.25-0.94, P=0.033). Conclusions: The incidence of MACE in patients who have undergone PCI is significantly associated with serum EPA/AA ratio.

UR - http://www.scopus.com/inward/record.url?scp=84856249003&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856249003&partnerID=8YFLogxK

U2 - 10.1253/circj.CJ-11-0941

DO - 10.1253/circj.CJ-11-0941

M3 - Article

C2 - 22156311

AN - SCOPUS:84856249003

VL - 76

SP - 423

EP - 429

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 2

ER -