Ratios of serum eicosapentaenoic acid to arachidonic acid and docosahexaenoic acid to arachidonic acid were inversely associated with serum resistin levels: The Hisayama Study

Mayu Higashioka, Yoichiro Hirakawa, Ryoichi Kawamura, Takanori Honda, Jun Hata, Daigo Yoshida, Yasunori Takata, Takanari Kitazono, Haruhiko Osawa, Toshiharu Ninomiya

Research output: Contribution to journalArticle

Abstract

Aims/Introduction: Resistin is an adipocyte-derived polypeptide that leads to the progression of insulin resistance and subsequent atherosclerosis. Some studies have reported an association between self-reported intake of n−3 polyunsaturated fatty acids (PUFAs) and serum resistin levels. However, no studies have investigated the association between the ratio of serum levels of n−3 to serum n−6 PUFAs and the serum resistin concentration in the general population. Materials and Methods: We carried out a cross-sectional study of 3,200 community-dwelling Japanese individuals aged ≥40 years in 2002–2003. The ratios of serum eicosapentaenoic acid or docosahexaenoic acid to arachidonic acid (AA) were categorized into quartiles. The associations of serum eicosapentaenoic acid/AA and docosahexaenoic acid/AA with the serum resistin concentration were assessed using linear regression models with adjustment for potential confounding factors. Results: The geometric mean of serum resistin was 10.3 ng/mL. The age- and sex-adjusted geometric mean of serum resistin decreased significantly with increased levels of serum eicosapentaenoic acid/AA (quartile 1: 11.3 ng/mL; quartile 2: 10.6 ng/mL; quartile 3: 10.3 ng/mL; quartile 4: 9.3 ng/mL; P for trend <0.001). A similar association was observed for serum docosahexaenoic acid/AA (quartile 1: 11.1 ng/mL; quartile 2: 10.6 ng/mL; quartile 3: 10.1 ng/mL; quartile 4: 9.7 ng/mL; P for trend <0.001). An adjustment for potential confounding factors did not change these associations. Conclusions: Higher ratios of serum n−3 to n−6 PUFAs were associated with lower serum resistin levels. Consumption of a large amount of n−3 PUFAs might have desirable effects on resistin-mediated diseases.

Original languageEnglish
JournalJournal of Diabetes Investigation
DOIs
Publication statusAccepted/In press - Jan 1 2019

Fingerprint

Resistin
Eicosapentaenoic Acid
Docosahexaenoic Acids
Arachidonic Acid
Serum
Omega-3 Fatty Acids
Unsaturated Fatty Acids
Linear Models
Independent Living
Adipocytes
Insulin Resistance

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

@article{224a2525e0374ec1ad7a81c5563e5651,
title = "Ratios of serum eicosapentaenoic acid to arachidonic acid and docosahexaenoic acid to arachidonic acid were inversely associated with serum resistin levels: The Hisayama Study",
abstract = "Aims/Introduction: Resistin is an adipocyte-derived polypeptide that leads to the progression of insulin resistance and subsequent atherosclerosis. Some studies have reported an association between self-reported intake of n−3 polyunsaturated fatty acids (PUFAs) and serum resistin levels. However, no studies have investigated the association between the ratio of serum levels of n−3 to serum n−6 PUFAs and the serum resistin concentration in the general population. Materials and Methods: We carried out a cross-sectional study of 3,200 community-dwelling Japanese individuals aged ≥40 years in 2002–2003. The ratios of serum eicosapentaenoic acid or docosahexaenoic acid to arachidonic acid (AA) were categorized into quartiles. The associations of serum eicosapentaenoic acid/AA and docosahexaenoic acid/AA with the serum resistin concentration were assessed using linear regression models with adjustment for potential confounding factors. Results: The geometric mean of serum resistin was 10.3 ng/mL. The age- and sex-adjusted geometric mean of serum resistin decreased significantly with increased levels of serum eicosapentaenoic acid/AA (quartile 1: 11.3 ng/mL; quartile 2: 10.6 ng/mL; quartile 3: 10.3 ng/mL; quartile 4: 9.3 ng/mL; P for trend <0.001). A similar association was observed for serum docosahexaenoic acid/AA (quartile 1: 11.1 ng/mL; quartile 2: 10.6 ng/mL; quartile 3: 10.1 ng/mL; quartile 4: 9.7 ng/mL; P for trend <0.001). An adjustment for potential confounding factors did not change these associations. Conclusions: Higher ratios of serum n−3 to n−6 PUFAs were associated with lower serum resistin levels. Consumption of a large amount of n−3 PUFAs might have desirable effects on resistin-mediated diseases.",
author = "Mayu Higashioka and Yoichiro Hirakawa and Ryoichi Kawamura and Takanori Honda and Jun Hata and Daigo Yoshida and Yasunori Takata and Takanari Kitazono and Haruhiko Osawa and Toshiharu Ninomiya",
year = "2019",
month = "1",
day = "1",
doi = "10.1111/jdi.13129",
language = "English",
journal = "Journal of Diabetes Investigation",
issn = "2040-1116",
publisher = "Blackwell Publishing Asia Pty Ltd",

}

TY - JOUR

T1 - Ratios of serum eicosapentaenoic acid to arachidonic acid and docosahexaenoic acid to arachidonic acid were inversely associated with serum resistin levels

T2 - The Hisayama Study

AU - Higashioka, Mayu

AU - Hirakawa, Yoichiro

AU - Kawamura, Ryoichi

AU - Honda, Takanori

AU - Hata, Jun

AU - Yoshida, Daigo

AU - Takata, Yasunori

AU - Kitazono, Takanari

AU - Osawa, Haruhiko

AU - Ninomiya, Toshiharu

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Aims/Introduction: Resistin is an adipocyte-derived polypeptide that leads to the progression of insulin resistance and subsequent atherosclerosis. Some studies have reported an association between self-reported intake of n−3 polyunsaturated fatty acids (PUFAs) and serum resistin levels. However, no studies have investigated the association between the ratio of serum levels of n−3 to serum n−6 PUFAs and the serum resistin concentration in the general population. Materials and Methods: We carried out a cross-sectional study of 3,200 community-dwelling Japanese individuals aged ≥40 years in 2002–2003. The ratios of serum eicosapentaenoic acid or docosahexaenoic acid to arachidonic acid (AA) were categorized into quartiles. The associations of serum eicosapentaenoic acid/AA and docosahexaenoic acid/AA with the serum resistin concentration were assessed using linear regression models with adjustment for potential confounding factors. Results: The geometric mean of serum resistin was 10.3 ng/mL. The age- and sex-adjusted geometric mean of serum resistin decreased significantly with increased levels of serum eicosapentaenoic acid/AA (quartile 1: 11.3 ng/mL; quartile 2: 10.6 ng/mL; quartile 3: 10.3 ng/mL; quartile 4: 9.3 ng/mL; P for trend <0.001). A similar association was observed for serum docosahexaenoic acid/AA (quartile 1: 11.1 ng/mL; quartile 2: 10.6 ng/mL; quartile 3: 10.1 ng/mL; quartile 4: 9.7 ng/mL; P for trend <0.001). An adjustment for potential confounding factors did not change these associations. Conclusions: Higher ratios of serum n−3 to n−6 PUFAs were associated with lower serum resistin levels. Consumption of a large amount of n−3 PUFAs might have desirable effects on resistin-mediated diseases.

AB - Aims/Introduction: Resistin is an adipocyte-derived polypeptide that leads to the progression of insulin resistance and subsequent atherosclerosis. Some studies have reported an association between self-reported intake of n−3 polyunsaturated fatty acids (PUFAs) and serum resistin levels. However, no studies have investigated the association between the ratio of serum levels of n−3 to serum n−6 PUFAs and the serum resistin concentration in the general population. Materials and Methods: We carried out a cross-sectional study of 3,200 community-dwelling Japanese individuals aged ≥40 years in 2002–2003. The ratios of serum eicosapentaenoic acid or docosahexaenoic acid to arachidonic acid (AA) were categorized into quartiles. The associations of serum eicosapentaenoic acid/AA and docosahexaenoic acid/AA with the serum resistin concentration were assessed using linear regression models with adjustment for potential confounding factors. Results: The geometric mean of serum resistin was 10.3 ng/mL. The age- and sex-adjusted geometric mean of serum resistin decreased significantly with increased levels of serum eicosapentaenoic acid/AA (quartile 1: 11.3 ng/mL; quartile 2: 10.6 ng/mL; quartile 3: 10.3 ng/mL; quartile 4: 9.3 ng/mL; P for trend <0.001). A similar association was observed for serum docosahexaenoic acid/AA (quartile 1: 11.1 ng/mL; quartile 2: 10.6 ng/mL; quartile 3: 10.1 ng/mL; quartile 4: 9.7 ng/mL; P for trend <0.001). An adjustment for potential confounding factors did not change these associations. Conclusions: Higher ratios of serum n−3 to n−6 PUFAs were associated with lower serum resistin levels. Consumption of a large amount of n−3 PUFAs might have desirable effects on resistin-mediated diseases.

UR - http://www.scopus.com/inward/record.url?scp=85073798884&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073798884&partnerID=8YFLogxK

U2 - 10.1111/jdi.13129

DO - 10.1111/jdi.13129

M3 - Article

C2 - 31433904

AN - SCOPUS:85073798884

JO - Journal of Diabetes Investigation

JF - Journal of Diabetes Investigation

SN - 2040-1116

ER -