Re-entry of tumour B cells into the cycle of somatic mutation and isotype switching in follicular lymphoma

Satoshi Shiokawa, Takamitsu Matsushima, Ilseung Choi, Yasunobu Abe, Motoaki Shiratsuchi, Youko Suehiro, Koichiro Muta, Koichi Ohshima, Junji Nishimura

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Sequencing of the immunoglobulin (Ig) gene transcripts of the tumour B cells in lymph node (LN) and bone marrow (BM) from a follicular lymphoma (FL) patient associated with multiple myeloma identified two dominant clones. One of the clones, present in both LN and BM, had somatic mutations and extensive clonal diversity. Among the diversified clones, two dominant populations of identical sequences (group I and II) were present. Group II was a descendant population of group I and had nine more somatic mutations. Group I contained μ-, δ-, γ- and α-expressing clones. Group II clones contained mainly μ- and δ-expressing clones. These findings showed that somatic mutation and isotype switching occurred repeatedly in this patient.

Original languageEnglish
Pages (from-to)492-495
Number of pages4
JournalBritish Journal of Haematology
Volume120
Issue number3
DOIs
Publication statusPublished - Feb 1 2003

Fingerprint

Immunoglobulin Class Switching
Follicular Lymphoma
Cell Cycle
B-Lymphocytes
Clone Cells
Mutation
Neoplasms
Lymph Nodes
Bone Marrow
Immunoglobulin Genes
Multiple Myeloma
Population Groups
Population

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Re-entry of tumour B cells into the cycle of somatic mutation and isotype switching in follicular lymphoma. / Shiokawa, Satoshi; Matsushima, Takamitsu; Choi, Ilseung; Abe, Yasunobu; Shiratsuchi, Motoaki; Suehiro, Youko; Muta, Koichiro; Ohshima, Koichi; Nishimura, Junji.

In: British Journal of Haematology, Vol. 120, No. 3, 01.02.2003, p. 492-495.

Research output: Contribution to journalArticle

Shiokawa, S, Matsushima, T, Choi, I, Abe, Y, Shiratsuchi, M, Suehiro, Y, Muta, K, Ohshima, K & Nishimura, J 2003, 'Re-entry of tumour B cells into the cycle of somatic mutation and isotype switching in follicular lymphoma', British Journal of Haematology, vol. 120, no. 3, pp. 492-495. https://doi.org/10.1046/j.1365-2141.2003.04079.x
Shiokawa, Satoshi ; Matsushima, Takamitsu ; Choi, Ilseung ; Abe, Yasunobu ; Shiratsuchi, Motoaki ; Suehiro, Youko ; Muta, Koichiro ; Ohshima, Koichi ; Nishimura, Junji. / Re-entry of tumour B cells into the cycle of somatic mutation and isotype switching in follicular lymphoma. In: British Journal of Haematology. 2003 ; Vol. 120, No. 3. pp. 492-495.
@article{c5b66221ad844376b62bfc22437a2486,
title = "Re-entry of tumour B cells into the cycle of somatic mutation and isotype switching in follicular lymphoma",
abstract = "Sequencing of the immunoglobulin (Ig) gene transcripts of the tumour B cells in lymph node (LN) and bone marrow (BM) from a follicular lymphoma (FL) patient associated with multiple myeloma identified two dominant clones. One of the clones, present in both LN and BM, had somatic mutations and extensive clonal diversity. Among the diversified clones, two dominant populations of identical sequences (group I and II) were present. Group II was a descendant population of group I and had nine more somatic mutations. Group I contained μ-, δ-, γ- and α-expressing clones. Group II clones contained mainly μ- and δ-expressing clones. These findings showed that somatic mutation and isotype switching occurred repeatedly in this patient.",
author = "Satoshi Shiokawa and Takamitsu Matsushima and Ilseung Choi and Yasunobu Abe and Motoaki Shiratsuchi and Youko Suehiro and Koichiro Muta and Koichi Ohshima and Junji Nishimura",
year = "2003",
month = "2",
day = "1",
doi = "10.1046/j.1365-2141.2003.04079.x",
language = "English",
volume = "120",
pages = "492--495",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Re-entry of tumour B cells into the cycle of somatic mutation and isotype switching in follicular lymphoma

AU - Shiokawa, Satoshi

AU - Matsushima, Takamitsu

AU - Choi, Ilseung

AU - Abe, Yasunobu

AU - Shiratsuchi, Motoaki

AU - Suehiro, Youko

AU - Muta, Koichiro

AU - Ohshima, Koichi

AU - Nishimura, Junji

PY - 2003/2/1

Y1 - 2003/2/1

N2 - Sequencing of the immunoglobulin (Ig) gene transcripts of the tumour B cells in lymph node (LN) and bone marrow (BM) from a follicular lymphoma (FL) patient associated with multiple myeloma identified two dominant clones. One of the clones, present in both LN and BM, had somatic mutations and extensive clonal diversity. Among the diversified clones, two dominant populations of identical sequences (group I and II) were present. Group II was a descendant population of group I and had nine more somatic mutations. Group I contained μ-, δ-, γ- and α-expressing clones. Group II clones contained mainly μ- and δ-expressing clones. These findings showed that somatic mutation and isotype switching occurred repeatedly in this patient.

AB - Sequencing of the immunoglobulin (Ig) gene transcripts of the tumour B cells in lymph node (LN) and bone marrow (BM) from a follicular lymphoma (FL) patient associated with multiple myeloma identified two dominant clones. One of the clones, present in both LN and BM, had somatic mutations and extensive clonal diversity. Among the diversified clones, two dominant populations of identical sequences (group I and II) were present. Group II was a descendant population of group I and had nine more somatic mutations. Group I contained μ-, δ-, γ- and α-expressing clones. Group II clones contained mainly μ- and δ-expressing clones. These findings showed that somatic mutation and isotype switching occurred repeatedly in this patient.

UR - http://www.scopus.com/inward/record.url?scp=0037323865&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037323865&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2141.2003.04079.x

DO - 10.1046/j.1365-2141.2003.04079.x

M3 - Article

VL - 120

SP - 492

EP - 495

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 3

ER -