Reaction of calcium phosphate cements with different amounts of tetracalcium phosphate and dicalcium phosphate anhydrous

Kunio Ishikawa, Shozo Takagi, Laurence C. Chow, Kazuomi Suzuki

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Calcium phosphate cements (CPCs) with different amounts of tetracalcium phosphate (TTCP) and dicalcium phosphate anhydrous (DCPA) (TTCP/DCPA molar ratio from 0.25 to 2.00) were prepared to further understand the setting reaction and the factors that could influence the properties of CPCs. Quantitative X-ray diffraction patterns, Fourier transform IR spectra, and diametral tensile strength of the set mass were measured along with pH measurements of the CPC suspension. Calcium-deficient hydroxyapatite (d-HAP) with a calcium to phosphate molar ratio of approximately 1.5 was formed initially in the CPC setting consisting of an equimolar mixture of TTCP and DCPA. This gradually transformed into stoichiometric HA (s-HA) with increasing incubation time. The s-HA was formed in the initial stage when the CPC contained an excess amount of TTCP. In contrast, maturation to s-HAP was slow when the CPC contained excess amounts of DCPA. The highest mechanical strength of set CPC was associated with an equimolar mixture of TTCP and DCPA, and the mechanical strength decreased as the TTCP/DCPA molar ratio deviated from 1.00. We concluded, therefore, that the setting reaction and the nature of the resulting set mass are dependent on the molar ratios of TTCP and DCPA.

Original languageEnglish
Pages (from-to)504-510
Number of pages7
JournalJournal of Biomedical Materials Research
Volume46
Issue number4
DOIs
Publication statusPublished - Sep 15 1999

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Calcium phosphate
Cements
Phosphates
Strength of materials
Calcium
Durapatite
calcium phosphate
tetracalcium phosphate
anhydrous dibasic calcium phosphate
Diffraction patterns
Suspensions
Fourier transforms
Tensile strength
X ray diffraction
Bone cement
Hydroxyapatite

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

Cite this

Reaction of calcium phosphate cements with different amounts of tetracalcium phosphate and dicalcium phosphate anhydrous. / Ishikawa, Kunio; Takagi, Shozo; Chow, Laurence C.; Suzuki, Kazuomi.

In: Journal of Biomedical Materials Research, Vol. 46, No. 4, 15.09.1999, p. 504-510.

Research output: Contribution to journalArticle

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