Reactive Cysteine Persulphides: Occurrence, Biosynthesis, Antioxidant Activity, Methodologies, and Bacterial Persulphide Signalling

Tomohiro Sawa, Katsuhiko Ono, Hiroyasu Tsutsuki, Tianli Zhang, Tomoaki Ida, Motohiro Nishida, Takaaki Akaike

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

Cysteine hydropersulphide (CysSSH) is a cysteine derivative having one additional sulphur atom bound to a cysteinyl thiol group. Recent advances in the development of analytical methods for detection and quantification of persulphides and polysulphides have revealed the biological presence, in both prokaryotes and eukaryotes, of hydropersulphides in diverse forms such as CysSSH, homocysteine hydropersulphide, glutathione hydropersulphide, bacillithiol hydropersulphide, coenzyme A hydropersulphide, and protein hydropersulphides. Owing to the chemical reactivity of the persulphide moiety, biological systems utilize persulphides as important intermediates in the synthesis of various sulphur-containing biomolecules. Accumulating evidence has revealed another important feature of persulphides: their potent reducing activity, which implies that they are implicated in the regulation of redox signalling and antioxidant functions. In this chapter, we discuss the biological occurrence and possible biosynthetic mechanisms of CysSSH and related persulphides, and we include descriptions of recent advances in the analytical methods that have been used to detect and quantitate persulphide species. We also discuss the antioxidant activity of persulphide species that contributes to protecting cells from reactive oxygen species-associated damage, and we examine the signalling roles of CysSSH in bacteria.

Original languageEnglish
Title of host publicationNitric Oxide and Other Small Signalling Molecules
EditorsRobert K. Poole
PublisherAcademic Press
Pages1-28
Number of pages28
ISBN (Print)9780128144138
DOIs
Publication statusPublished - Jan 1 2018

Publication series

NameAdvances in Microbial Physiology
Volume72
ISSN (Print)0065-2911

Fingerprint

Antioxidants
Sulfur
Cysteine
Homocysteine
Coenzyme A
persulfides
cysteine persulfide
Eukaryota
Sulfhydryl Compounds
Oxidation-Reduction
Glutathione
Reactive Oxygen Species
Bacteria
Proteins

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Physiology

Cite this

Sawa, T., Ono, K., Tsutsuki, H., Zhang, T., Ida, T., Nishida, M., & Akaike, T. (2018). Reactive Cysteine Persulphides: Occurrence, Biosynthesis, Antioxidant Activity, Methodologies, and Bacterial Persulphide Signalling. In R. K. Poole (Ed.), Nitric Oxide and Other Small Signalling Molecules (pp. 1-28). (Advances in Microbial Physiology; Vol. 72). Academic Press. https://doi.org/10.1016/bs.ampbs.2018.01.002

Reactive Cysteine Persulphides : Occurrence, Biosynthesis, Antioxidant Activity, Methodologies, and Bacterial Persulphide Signalling. / Sawa, Tomohiro; Ono, Katsuhiko; Tsutsuki, Hiroyasu; Zhang, Tianli; Ida, Tomoaki; Nishida, Motohiro; Akaike, Takaaki.

Nitric Oxide and Other Small Signalling Molecules. ed. / Robert K. Poole. Academic Press, 2018. p. 1-28 (Advances in Microbial Physiology; Vol. 72).

Research output: Chapter in Book/Report/Conference proceedingChapter

Sawa, T, Ono, K, Tsutsuki, H, Zhang, T, Ida, T, Nishida, M & Akaike, T 2018, Reactive Cysteine Persulphides: Occurrence, Biosynthesis, Antioxidant Activity, Methodologies, and Bacterial Persulphide Signalling. in RK Poole (ed.), Nitric Oxide and Other Small Signalling Molecules. Advances in Microbial Physiology, vol. 72, Academic Press, pp. 1-28. https://doi.org/10.1016/bs.ampbs.2018.01.002
Sawa T, Ono K, Tsutsuki H, Zhang T, Ida T, Nishida M et al. Reactive Cysteine Persulphides: Occurrence, Biosynthesis, Antioxidant Activity, Methodologies, and Bacterial Persulphide Signalling. In Poole RK, editor, Nitric Oxide and Other Small Signalling Molecules. Academic Press. 2018. p. 1-28. (Advances in Microbial Physiology). https://doi.org/10.1016/bs.ampbs.2018.01.002
Sawa, Tomohiro ; Ono, Katsuhiko ; Tsutsuki, Hiroyasu ; Zhang, Tianli ; Ida, Tomoaki ; Nishida, Motohiro ; Akaike, Takaaki. / Reactive Cysteine Persulphides : Occurrence, Biosynthesis, Antioxidant Activity, Methodologies, and Bacterial Persulphide Signalling. Nitric Oxide and Other Small Signalling Molecules. editor / Robert K. Poole. Academic Press, 2018. pp. 1-28 (Advances in Microbial Physiology).
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