Reading molecular structural Information of amino acids through an extended molecular pairing technique

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have recently reported the formation of developed nanofibers upon mixing ATP and certain cationic cyanine dyes. This combination is selected through the combinatorial mixing of ATP and many cationic molecules, allowing to develop nanofibers consisted of ATP and cyanine dye molecules1). In this work, the molecular pairing approach is applied to amino acids. As amino acids do not specifically interact with cationic dyes, they are first converted to anionic isoindole derivatives by the reaction with o-phthalaldehyde and 2-mercaptoethanesulfonic acid. When an isoindole product of gultamic acid was mixed with cationic cyanine dyes, immediate color change occurred from pink to orange. The blue-shifted absorption of cyanine dyes implies the formation of developed chiral assemblies with excitation energy delocalized among the parallel-aligned chromophores. Transmission electron microscopy revealed the formation of nanofibers with ca. 50 nm in width and several micrometers in length. These spectroscopic properties and nano structures of the mixtures changed depending on the chemical structures of amino acids.

Original languageEnglish
Title of host publication55th SPSJ Symposium on Macromolecules
Pages4739-4740
Number of pages2
Volume55
Edition2
Publication statusPublished - 2006
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: Sep 20 2006Sep 22 2006

Other

Other55th Society of Polymer Science Japan Symposium on Macromolecules
CountryJapan
CityToyama
Period9/20/069/22/06

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Amino acids
Dyes
Adenosinetriphosphate
Nanofibers
Acids
Excitation energy
Chromophores
Transmission electron microscopy
Color
Derivatives
Molecules

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Reading molecular structural Information of amino acids through an extended molecular pairing technique. / Shiraki, Tomohiro; Morikawa, Masa-Aki; Kimizuka, Nobuo.

55th SPSJ Symposium on Macromolecules. Vol. 55 2. ed. 2006. p. 4739-4740.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Shiraki, T, Morikawa, M-A & Kimizuka, N 2006, Reading molecular structural Information of amino acids through an extended molecular pairing technique. in 55th SPSJ Symposium on Macromolecules. 2 edn, vol. 55, pp. 4739-4740, 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan, 9/20/06.
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