TY - JOUR
T1 - Real-time neurofeedback to modulate β-band power in the subthalamic nucleus in Parkinson’s disease patients
AU - Fukuma, Ryohei
AU - Yanagisawa, Takufumi
AU - Tanaka, Masataka
AU - Yoshida, Fumiaki
AU - Hosomi, Koichi
AU - Oshino, Satoru
AU - Tani, Naoki
AU - Kishima, Haruhiko
N1 - Funding Information:
This work was supported by the Brain/MINDS by AMED, and in part by SRPBS by MEXT and AMED; JST PRESTO (JPMJPR1506 and JPMJPR178C), CREST(JPMJCR18A5) and ERATO(JPMJER1801); Grants-in-Aid for Scientific Research from KAKENHI (JP24700419, JP26560467, JP22700435, JP15H05710, and JP16K10787); SICP from AMED; TERUMO Foundation for Life Sciences and Arts; and the Japan Foundation of Aging and Health. We thank the patients for their participation in this study.
Publisher Copyright:
© 2018 Fukuma et al.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - The β-band oscillation in the subthalamic nucleus (STN) is a therapeutic target for Parkinson’s disease. Previous studies demonstrated that L -DOPA decreases the β-band (13–30 Hz) oscillations with improvement of motor symptoms. However, it has not been elucidated whether patients with Parkinson’s disease are able to control the β-band oscillation voluntarily. Here, we hypothesized that neurofeedback training to control the β-band power in the STN induces plastic changes in the STN of individuals with Parkinson’s disease. We recorded the signals from STN deep-brain stimulation electrodes during operations to replace implantable pulse generators in eight human patients (3 male) with bilateral electrodes. Four patients were induced to decrease the β-band power during the feedback training (down-training condition), whereas the other patients were induced to increase (up-training condition). All patients were blinded to their assigned condition. Adjacent contacts that showed the highest β-band power were selected for the feedback. During the 10 min training, patients were shown a circle whose diameter was controlled by the β-band power of the selected contacts. Powers in the β-band during 5 min resting sessions recorded before and after the feedback were compared. In the down-training condition, the β-band power of the selected contacts decreased significantly after feedback in all four patients (p < 0.05). In contrast, the β-band power significantly increased after feedback in two of four patients in the up-training condition. Overall, the patients could voluntarily control the β-band power in STN in the instructed direction (p < 0.05) through neurofeedback.
AB - The β-band oscillation in the subthalamic nucleus (STN) is a therapeutic target for Parkinson’s disease. Previous studies demonstrated that L -DOPA decreases the β-band (13–30 Hz) oscillations with improvement of motor symptoms. However, it has not been elucidated whether patients with Parkinson’s disease are able to control the β-band oscillation voluntarily. Here, we hypothesized that neurofeedback training to control the β-band power in the STN induces plastic changes in the STN of individuals with Parkinson’s disease. We recorded the signals from STN deep-brain stimulation electrodes during operations to replace implantable pulse generators in eight human patients (3 male) with bilateral electrodes. Four patients were induced to decrease the β-band power during the feedback training (down-training condition), whereas the other patients were induced to increase (up-training condition). All patients were blinded to their assigned condition. Adjacent contacts that showed the highest β-band power were selected for the feedback. During the 10 min training, patients were shown a circle whose diameter was controlled by the β-band power of the selected contacts. Powers in the β-band during 5 min resting sessions recorded before and after the feedback were compared. In the down-training condition, the β-band power of the selected contacts decreased significantly after feedback in all four patients (p < 0.05). In contrast, the β-band power significantly increased after feedback in two of four patients in the up-training condition. Overall, the patients could voluntarily control the β-band power in STN in the instructed direction (p < 0.05) through neurofeedback.
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U2 - 10.1523/ENEURO.0246-18.2018
DO - 10.1523/ENEURO.0246-18.2018
M3 - Article
C2 - 30627648
AN - SCOPUS:85059796294
VL - 5
JO - eNeuro
JF - eNeuro
SN - 2373-2822
IS - 6
M1 - e0246-18.2018
ER -