Rearrangement of immunoglobulin heavy chain genes and t3 expression in the absence of rearrangement of t-cell receptor β-chain gene in a patient with t-cell malignant lymphoma

Hiroyasu Ogawa, Haruo Sugiyama, Yoshihiro Oka, Toyoki Maeda, Toshihisa Komori, Yoshihiko Tani, Seigou Miyake, Toshihiro Soma, Ryoji Maekura, Chikao Yutani, Tohru Masaoka, Susumu Kishimoto

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We describe the rearrangement of immunoglobulin genes and T3 expression in the absence of rearrangement of T-cell receptor β-chain genes in a patient wih T-cell malignant lymphoma. He had a mediastinal mass and his lymphoma cells expressed T-cell antigens (OKT3+, OKT9+, and OKT10+). When we examined genomic DNA from the lymphoma cells, we detected the rearrangement of immunoglobulin heavy chain genes with a germ-line configuration of light chain genes and no rearrangement of T-cell receptor β-chain gene. These results indicated that the rearrangement of immunoglobulin genes could occur in T-cell malignant lymphoma, and that T3 antigen could be expressed prior to the rearrangement of T-cell receptor β-chain genes under certain circumstances.

Original languageEnglish
Pages (from-to)1369-1375
Number of pages7
JournalLeukemia Research
Volume10
Issue number12
DOIs
Publication statusPublished - 1986
Externally publishedYes

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Immunoglobulin Heavy Chain Genes
T-Cell Receptor Genes
Lymphoma
Gene Expression
Immunoglobulin Genes
T-Cell Lymphoma
Genes
CD3 Antigens
Muromonab-CD3
Gene Rearrangement
Viral Tumor Antigens
Germ Cells
T-Lymphocytes
Light
DNA

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Rearrangement of immunoglobulin heavy chain genes and t3 expression in the absence of rearrangement of t-cell receptor β-chain gene in a patient with t-cell malignant lymphoma. / Ogawa, Hiroyasu; Sugiyama, Haruo; Oka, Yoshihiro; Maeda, Toyoki; Komori, Toshihisa; Tani, Yoshihiko; Miyake, Seigou; Soma, Toshihiro; Maekura, Ryoji; Yutani, Chikao; Masaoka, Tohru; Kishimoto, Susumu.

In: Leukemia Research, Vol. 10, No. 12, 1986, p. 1369-1375.

Research output: Contribution to journalArticle

Ogawa, Hiroyasu ; Sugiyama, Haruo ; Oka, Yoshihiro ; Maeda, Toyoki ; Komori, Toshihisa ; Tani, Yoshihiko ; Miyake, Seigou ; Soma, Toshihiro ; Maekura, Ryoji ; Yutani, Chikao ; Masaoka, Tohru ; Kishimoto, Susumu. / Rearrangement of immunoglobulin heavy chain genes and t3 expression in the absence of rearrangement of t-cell receptor β-chain gene in a patient with t-cell malignant lymphoma. In: Leukemia Research. 1986 ; Vol. 10, No. 12. pp. 1369-1375.
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abstract = "We describe the rearrangement of immunoglobulin genes and T3 expression in the absence of rearrangement of T-cell receptor β-chain genes in a patient wih T-cell malignant lymphoma. He had a mediastinal mass and his lymphoma cells expressed T-cell antigens (OKT3+, OKT9+, and OKT10+). When we examined genomic DNA from the lymphoma cells, we detected the rearrangement of immunoglobulin heavy chain genes with a germ-line configuration of light chain genes and no rearrangement of T-cell receptor β-chain gene. These results indicated that the rearrangement of immunoglobulin genes could occur in T-cell malignant lymphoma, and that T3 antigen could be expressed prior to the rearrangement of T-cell receptor β-chain genes under certain circumstances.",
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T1 - Rearrangement of immunoglobulin heavy chain genes and t3 expression in the absence of rearrangement of t-cell receptor β-chain gene in a patient with t-cell malignant lymphoma

AU - Ogawa, Hiroyasu

AU - Sugiyama, Haruo

AU - Oka, Yoshihiro

AU - Maeda, Toyoki

AU - Komori, Toshihisa

AU - Tani, Yoshihiko

AU - Miyake, Seigou

AU - Soma, Toshihiro

AU - Maekura, Ryoji

AU - Yutani, Chikao

AU - Masaoka, Tohru

AU - Kishimoto, Susumu

PY - 1986

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AB - We describe the rearrangement of immunoglobulin genes and T3 expression in the absence of rearrangement of T-cell receptor β-chain genes in a patient wih T-cell malignant lymphoma. He had a mediastinal mass and his lymphoma cells expressed T-cell antigens (OKT3+, OKT9+, and OKT10+). When we examined genomic DNA from the lymphoma cells, we detected the rearrangement of immunoglobulin heavy chain genes with a germ-line configuration of light chain genes and no rearrangement of T-cell receptor β-chain gene. These results indicated that the rearrangement of immunoglobulin genes could occur in T-cell malignant lymphoma, and that T3 antigen could be expressed prior to the rearrangement of T-cell receptor β-chain genes under certain circumstances.

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