Reassessment and clinicopathological prognostic factors of malignant fibrous histiocytoma of soft parts

Yoshinao Oda, Sadafumi Tamiya, Yumi Oshiro, Yoichi Hachitanda, Naoko Kinukawa, Yukihide Iwamoto, Masazumi Tsuneyoshi

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Abstract

Recently, the category of malignant fibrous histiocytoma (MFH) has been under discussion and new entities resembling MFH have appeared. To clarify the recent situation regarding MFH, we reassessed previously diagnosed MFH cases in accordance with the most up-to-date diagnostic criteria, which included allied tumors. We carefully reassessed 428 cases that had been diagnosed in our institute during the past 28 years. Moreover, we searched for clinicopathological prognostic factors among the cases that were finally diagnosed as MFH. Among the 428 cases, 138 cases had their diagnoses changed. The revised cases included 78 leiomyosarcomas (57%; ordinary leiomyosarcoma, 45 cases; pleomorphic leiomyosarcoma, 23 cases; myxoid leiomyosarcoma, 10 cases), 12 liposarcomas (9%; pleomorphic liposarcoma, 11 cases; dedifferentiated liposarcoma, one case), seven dermatofibrosarcoma protuberans (5%), six unclassified sarcomas (4%), five primary or metastatic carcinomas (4%), four low-grade fibromyxoid sarcomas (3%), four inflammatory myofibroblastic tumors (3%), three rhabdomyosarcomas (2%), three malignant peripheral nerve sheath tumors (2%), three acral myxoinflammatory fibroblastic sarcomas (2%) and two atypical fibroxanthomas (1.5%). Among the 1974 soft tissue sarcomas registered in our institute, MFH (428 cases) had been the most common sarcoma, followed by liposarcoma, leiomyosarcoma and rhabdomyosarcoma. However, after reassessment, leiomyosarcoma proved to be the most common soft tissue sarcoma (322 cases), followed by 290 MFH, 273 liposarcomas and 202 rhabdomyosarcomas. Among these 290 cases finally diagnosed as MFH, survival data were available in 189 cases. Tumor location in the abdominal cavity, the retroperitoneum or the head and neck (P = 0.0024), tumor size of 5 cm or more (P < 0.0001), deep tumor location (P < 0.0001), high histological grade (grade 3) based on the French Federation of Cancer Centers' grading system (P = 0.0007), and high stage (stage III or IV) based on the American Joint Committee on Cancer (AJCC) staging system (P < 0.0001) were significantly worse prognostic factors by univariate analysis. In multivariate analysis, deep tumor location and high AJCC stage were independent adverse prognostic factors. We conclude that leiomyosarcoma is the most important differential diagnosis for MFH, especially pleomorphic leiomyosarcoma from storiform-pleomorphic type and myxoid leiomyosarcoma from myxoid type. Tumor depth and AJCC stage are the most important predictive prognostic factors in MFH.

Original languageEnglish
Pages (from-to)595-606
Number of pages12
JournalPathology International
Volume52
Issue number9
DOIs
Publication statusPublished - Nov 26 2002

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Malignant Fibrous Histiocytoma
Leiomyosarcoma
Liposarcoma
Sarcoma
Neoplasms
Rhabdomyosarcoma
Dermatofibrosarcoma
Abdominal Cavity
Neoplasm Staging
Neurilemmoma
Statistical Factor Analysis
Differential Diagnosis
Neck
Multivariate Analysis
Extremities
Head
Carcinoma

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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Reassessment and clinicopathological prognostic factors of malignant fibrous histiocytoma of soft parts. / Oda, Yoshinao; Tamiya, Sadafumi; Oshiro, Yumi; Hachitanda, Yoichi; Kinukawa, Naoko; Iwamoto, Yukihide; Tsuneyoshi, Masazumi.

In: Pathology International, Vol. 52, No. 9, 26.11.2002, p. 595-606.

Research output: Contribution to journalArticle

Oda, Y, Tamiya, S, Oshiro, Y, Hachitanda, Y, Kinukawa, N, Iwamoto, Y & Tsuneyoshi, M 2002, 'Reassessment and clinicopathological prognostic factors of malignant fibrous histiocytoma of soft parts', Pathology International, vol. 52, no. 9, pp. 595-606. https://doi.org/10.1046/j.1440-1827.2002.01399.x
Oda, Yoshinao ; Tamiya, Sadafumi ; Oshiro, Yumi ; Hachitanda, Yoichi ; Kinukawa, Naoko ; Iwamoto, Yukihide ; Tsuneyoshi, Masazumi. / Reassessment and clinicopathological prognostic factors of malignant fibrous histiocytoma of soft parts. In: Pathology International. 2002 ; Vol. 52, No. 9. pp. 595-606.
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