Reassessment of myometrial invasion in endometrial carcinoma

Tsunehisa Kaku, Nobuhiro Tsuruchi, Naoki Tsukamoto, Toshio Hirakawa, Toshiharu Kamura, Hitoo Nakano

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objective: To assess different methods of measuring the depth of myometrial invasion in endometrial carcinoma as a prognostic factor. Methods: Eighty-eight cases of stage I or II endometrial carcinoma treated initially by hysterectomy between 1979–1989 were reviewed histologically. Three methods of measuring myometrial invasion were evaluated: 1) percentage of invaded tumor thickness to whole thickness of myometrium, 2) percentage of whole tumor thickness to total thickness of tumor and myometrium, and 3) distance from the tumor-myometrial junction to the uterine serosa. We evaluated the effect of several factors on prognosis by multivariate analysis using Cox regression models. Results: Myometrial invasion determined by these three measurement methods was associated significantly with survival in a univariate analysis. When myometrial invasion assessed by each method and other prognostic factors were entered into a multivariate model, the distance from the tumor-myometrial junction to the uterine serosa, lymphvascular space invasion, and cervical stromal involvement were identified as independently significant prognostic factors. Conclusion: This method of evaluating myometrial invasion by measuring the distance from the tumor-myometrial junction to the uterine serosa was most useful as a correlate with survival. (Obstet Gynecol 1994;84:979-82)

Original languageEnglish
Pages (from-to)979-982
Number of pages4
JournalObstetrics and Gynecology
Volume84
Issue number6
Publication statusPublished - Dec 1994

Fingerprint

Endometrial Neoplasms
Serous Membrane
Neoplasms
Myometrium
Hysterectomy
Proportional Hazards Models
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

Kaku, T., Tsuruchi, N., Tsukamoto, N., Hirakawa, T., Kamura, T., & Nakano, H. (1994). Reassessment of myometrial invasion in endometrial carcinoma. Obstetrics and Gynecology, 84(6), 979-982.

Reassessment of myometrial invasion in endometrial carcinoma. / Kaku, Tsunehisa; Tsuruchi, Nobuhiro; Tsukamoto, Naoki; Hirakawa, Toshio; Kamura, Toshiharu; Nakano, Hitoo.

In: Obstetrics and Gynecology, Vol. 84, No. 6, 12.1994, p. 979-982.

Research output: Contribution to journalArticle

Kaku, T, Tsuruchi, N, Tsukamoto, N, Hirakawa, T, Kamura, T & Nakano, H 1994, 'Reassessment of myometrial invasion in endometrial carcinoma', Obstetrics and Gynecology, vol. 84, no. 6, pp. 979-982.
Kaku T, Tsuruchi N, Tsukamoto N, Hirakawa T, Kamura T, Nakano H. Reassessment of myometrial invasion in endometrial carcinoma. Obstetrics and Gynecology. 1994 Dec;84(6):979-982.
Kaku, Tsunehisa ; Tsuruchi, Nobuhiro ; Tsukamoto, Naoki ; Hirakawa, Toshio ; Kamura, Toshiharu ; Nakano, Hitoo. / Reassessment of myometrial invasion in endometrial carcinoma. In: Obstetrics and Gynecology. 1994 ; Vol. 84, No. 6. pp. 979-982.
@article{405f439c95214823bda94ff699997de6,
title = "Reassessment of myometrial invasion in endometrial carcinoma",
abstract = "Objective: To assess different methods of measuring the depth of myometrial invasion in endometrial carcinoma as a prognostic factor. Methods: Eighty-eight cases of stage I or II endometrial carcinoma treated initially by hysterectomy between 1979–1989 were reviewed histologically. Three methods of measuring myometrial invasion were evaluated: 1) percentage of invaded tumor thickness to whole thickness of myometrium, 2) percentage of whole tumor thickness to total thickness of tumor and myometrium, and 3) distance from the tumor-myometrial junction to the uterine serosa. We evaluated the effect of several factors on prognosis by multivariate analysis using Cox regression models. Results: Myometrial invasion determined by these three measurement methods was associated significantly with survival in a univariate analysis. When myometrial invasion assessed by each method and other prognostic factors were entered into a multivariate model, the distance from the tumor-myometrial junction to the uterine serosa, lymphvascular space invasion, and cervical stromal involvement were identified as independently significant prognostic factors. Conclusion: This method of evaluating myometrial invasion by measuring the distance from the tumor-myometrial junction to the uterine serosa was most useful as a correlate with survival. (Obstet Gynecol 1994;84:979-82)",
author = "Tsunehisa Kaku and Nobuhiro Tsuruchi and Naoki Tsukamoto and Toshio Hirakawa and Toshiharu Kamura and Hitoo Nakano",
year = "1994",
month = "12",
language = "English",
volume = "84",
pages = "979--982",
journal = "Obstetrics and Gynecology",
issn = "0029-7844",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Reassessment of myometrial invasion in endometrial carcinoma

AU - Kaku, Tsunehisa

AU - Tsuruchi, Nobuhiro

AU - Tsukamoto, Naoki

AU - Hirakawa, Toshio

AU - Kamura, Toshiharu

AU - Nakano, Hitoo

PY - 1994/12

Y1 - 1994/12

N2 - Objective: To assess different methods of measuring the depth of myometrial invasion in endometrial carcinoma as a prognostic factor. Methods: Eighty-eight cases of stage I or II endometrial carcinoma treated initially by hysterectomy between 1979–1989 were reviewed histologically. Three methods of measuring myometrial invasion were evaluated: 1) percentage of invaded tumor thickness to whole thickness of myometrium, 2) percentage of whole tumor thickness to total thickness of tumor and myometrium, and 3) distance from the tumor-myometrial junction to the uterine serosa. We evaluated the effect of several factors on prognosis by multivariate analysis using Cox regression models. Results: Myometrial invasion determined by these three measurement methods was associated significantly with survival in a univariate analysis. When myometrial invasion assessed by each method and other prognostic factors were entered into a multivariate model, the distance from the tumor-myometrial junction to the uterine serosa, lymphvascular space invasion, and cervical stromal involvement were identified as independently significant prognostic factors. Conclusion: This method of evaluating myometrial invasion by measuring the distance from the tumor-myometrial junction to the uterine serosa was most useful as a correlate with survival. (Obstet Gynecol 1994;84:979-82)

AB - Objective: To assess different methods of measuring the depth of myometrial invasion in endometrial carcinoma as a prognostic factor. Methods: Eighty-eight cases of stage I or II endometrial carcinoma treated initially by hysterectomy between 1979–1989 were reviewed histologically. Three methods of measuring myometrial invasion were evaluated: 1) percentage of invaded tumor thickness to whole thickness of myometrium, 2) percentage of whole tumor thickness to total thickness of tumor and myometrium, and 3) distance from the tumor-myometrial junction to the uterine serosa. We evaluated the effect of several factors on prognosis by multivariate analysis using Cox regression models. Results: Myometrial invasion determined by these three measurement methods was associated significantly with survival in a univariate analysis. When myometrial invasion assessed by each method and other prognostic factors were entered into a multivariate model, the distance from the tumor-myometrial junction to the uterine serosa, lymphvascular space invasion, and cervical stromal involvement were identified as independently significant prognostic factors. Conclusion: This method of evaluating myometrial invasion by measuring the distance from the tumor-myometrial junction to the uterine serosa was most useful as a correlate with survival. (Obstet Gynecol 1994;84:979-82)

UR - http://www.scopus.com/inward/record.url?scp=0028099936&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028099936&partnerID=8YFLogxK

M3 - Article

C2 - 7970481

AN - SCOPUS:0028099936

VL - 84

SP - 979

EP - 982

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

SN - 0029-7844

IS - 6

ER -