Recent advances in lactic acid production by microbial fermentation processes

Mohamed Ali Sayed Mohamed Abdelrahman, Yukihiro Tashiro, Kenji Sonomoto

Research output: Contribution to journalReview article

370 Citations (Scopus)

Abstract

Fermentative production of optically pure lactic acid has roused interest among researchers in recent years due to its high potential for applications in a wide range of fields. More specifically, the sharp increase in manufacturing of biodegradable polylactic acid (PLA) materials, green alternatives to petroleum-derived plastics, has significantly increased the global interest in lactic acid production. However, higher production costs have hindered the large-scale application of PLA because of the high price of lactic acid. Therefore, reduction of lactic acid production cost through utilization of inexpensive substrates and improvement of lactic acid production and productivity has become an important goal. Various methods have been employed for enhanced lactic acid production, including several bioprocess techniques facilitated by wild-type and/or engineered microbes. In this review, we will discuss lactic acid producers with relation to their fermentation characteristics and metabolism. Inexpensive fermentative substrates, such as dairy products, food and agro-industrial wastes, glycerol, and algal biomass alternatives to costly pure sugars and food crops are introduced. The operational modes and fermentation methods that have been recently reported to improve lactic acid production in terms of concentrations, yields, and productivities are summarized and compared. High cell density fermentation through immobilization and cell-recycling techniques are also addressed. Finally, advances in recovery processes and concluding remarks on the future outlook of lactic acid production are presented.

Original languageEnglish
Pages (from-to)877-902
Number of pages26
JournalBiotechnology Advances
Volume31
Issue number6
DOIs
Publication statusPublished - Nov 1 2013

Fingerprint

Lactic acid
Fermentation
Lactic Acid
Productivity
Dairy products
Industrial Waste
Costs and Cost Analysis
Food
Dairy Products
Acids
Industrial wastes
Petroleum
Recycling
Substrates
Glycerol
Metabolism
Sugars
Immobilization
Biomass
Plastics

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

Cite this

Recent advances in lactic acid production by microbial fermentation processes. / Abdelrahman, Mohamed Ali Sayed Mohamed; Tashiro, Yukihiro; Sonomoto, Kenji.

In: Biotechnology Advances, Vol. 31, No. 6, 01.11.2013, p. 877-902.

Research output: Contribution to journalReview article

Abdelrahman, Mohamed Ali Sayed Mohamed ; Tashiro, Yukihiro ; Sonomoto, Kenji. / Recent advances in lactic acid production by microbial fermentation processes. In: Biotechnology Advances. 2013 ; Vol. 31, No. 6. pp. 877-902.
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