Recent advances in radiation oncology: Intensity-modulated radiotherapy, a clinical perspective

Katsumasa Nakamura, Tomonari Sasaki, Ohga Saiji, Tadamasa Yoshitake, Kotaro Terashima, Kaori Asai, Keiji Matsumoto, Yoshiyuki Shioyama, Hiroshi Honda

Research output: Contribution to journalReview articlepeer-review

19 Citations (Scopus)


Radiotherapy plays an important role in the treatment of various malignancies, and intensity-modulated radiotherapy (IMRT) is an attractive option because it can deliver precise conformal radiation doses to the target while minimizing the dose to adjacent normal tissues. IMRT provides a highly conformal dose distribution by modulating the intensity of the radiation beam. A number of malignancies have been targeted by IMRT; this work reviews published data on the major disease sites treated with IMRT. The dosimetric advantage of IMRT has resulted in the significant reduction of adverse effects in some tumors. However, there are few clinical trials comparing IMRT and three-dimensional conformal radiotherapy (3D-CRT), and no definite increase in survival or the loco-regional control rate by IMRT has been demonstrated in many malignancies. IMRT also requires greater time and resources to complete compared to 3D-CRT. In addition, the cost-effectiveness of IMRT versus 3D-CRT has not yet been established.

Original languageEnglish
Pages (from-to)564-569
Number of pages6
JournalInternational Journal of Clinical Oncology
Issue number4
Publication statusPublished - Aug 2014

All Science Journal Classification (ASJC) codes

  • Surgery
  • Hematology
  • Oncology


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