Recent developments in nanowires for bio-applications from molecular to cellular levels

Sakon Rahong, Takao Yasui, Noritada Kaji, Yoshinobu Baba

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

This review highlights the most promising applications of nanowires for bioanalytical chemistry and medical diagnostics. The materials discussed here are metal oxide and Si semiconductors, which are integrated with various microfluidic systems. Nanowire structures offer desirable advantages such as a very small diameter size with a high aspect ratio and a high surface-to-volume ratio without grain boundaries; consequently, nanowires are promising tools to study biological systems. This review starts with the integration of nanowire structures into microfluidic systems, followed by the discussion of the advantages of nanowire structures in the separation, manipulation and purification of biomolecules (DNA, RNA and proteins). Next, some representative nanowire devices are introduced for biosensors from molecular to cellular levels based on electrical and optical approaches. Finally, we conclude the review by highlighting some bio-applications for nanowires and presenting the next challenges that must be overcome to improve the capabilities of nanowire structures for biological and medical systems.

Original languageEnglish
Pages (from-to)1126-1138
Number of pages13
JournalLab on a Chip
Volume16
Issue number7
DOIs
Publication statusPublished - Apr 7 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

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