Recent progress in understanding the mechanisms of Leydig cell differentiation

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Leydig cells in fetal and adult testes play pivotal roles in eliciting male characteristics by producing androgen. Although numerous studies of Leydig cells have been performed, the mechanisms for differentiation of the two cell types (fetal Leydig and adult Leydig cells), their developmental and functional relationship, and their differential characteristics remain largely unclear. Based on recent technical progress in genome-wide analysis and in vitro investigation, novel and fascinating observations concerning the issues above have been obtained. Focusing on fetal and adult Leydig cells, this review summarizes the recent progress that has advanced our understanding of the cells.

Original languageEnglish
Pages (from-to)39-46
Number of pages8
JournalMolecular and Cellular Endocrinology
Volume468
DOIs
Publication statusPublished - Jun 15 2018

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Leydig Cells
Androgens
Cell Differentiation
Genes
Testis
Genome

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Cite this

Recent progress in understanding the mechanisms of Leydig cell differentiation. / Inoue, Miki; Baba, Takashi; Morohashi, Ken-Ichirou.

In: Molecular and Cellular Endocrinology, Vol. 468, 15.06.2018, p. 39-46.

Research output: Contribution to journalReview article

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