TY - JOUR
T1 - Recent progress in understanding the mechanisms of Leydig cell differentiation
AU - Inoue, Miki
AU - Baba, Takashi
AU - Morohashi, Ken ichirou
N1 - Funding Information:
This work was supported by MEXT KAKENHI Grant Number 17H06427 (Grant-in-Aid for Scientific Research on Innovative Area for K. M.), by JSPS KAKENHI Grant Number 16H05142 (Grant-in-Aid for Scientific Research (B) for K. M.), Grant Number 16K08593 (Grant-in-Aid for Scientific Research (C) for T. K.), and Grant Number 17J03270 (Grant-in-Aid for JSPS Research Fellow for M. I.), by Takeda Science Foundation (T. B.), The Shin-Nihon of Advanced Medical Research Foundation (T. B.), and The Uehara Memorial Foundation (T. B.).
Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2018/6/15
Y1 - 2018/6/15
N2 - Leydig cells in fetal and adult testes play pivotal roles in eliciting male characteristics by producing androgen. Although numerous studies of Leydig cells have been performed, the mechanisms for differentiation of the two cell types (fetal Leydig and adult Leydig cells), their developmental and functional relationship, and their differential characteristics remain largely unclear. Based on recent technical progress in genome-wide analysis and in vitro investigation, novel and fascinating observations concerning the issues above have been obtained. Focusing on fetal and adult Leydig cells, this review summarizes the recent progress that has advanced our understanding of the cells.
AB - Leydig cells in fetal and adult testes play pivotal roles in eliciting male characteristics by producing androgen. Although numerous studies of Leydig cells have been performed, the mechanisms for differentiation of the two cell types (fetal Leydig and adult Leydig cells), their developmental and functional relationship, and their differential characteristics remain largely unclear. Based on recent technical progress in genome-wide analysis and in vitro investigation, novel and fascinating observations concerning the issues above have been obtained. Focusing on fetal and adult Leydig cells, this review summarizes the recent progress that has advanced our understanding of the cells.
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U2 - 10.1016/j.mce.2017.12.013
DO - 10.1016/j.mce.2017.12.013
M3 - Review article
C2 - 29309805
AN - SCOPUS:85042694364
SN - 0303-7207
VL - 468
SP - 39
EP - 46
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
ER -