TY - JOUR
T1 - Recent strategic advances for the activation of benzylic C–H bonds for the formation of C–C bonds
AU - Yazaki, Ryo
AU - Ohshima, Takashi
N1 - Funding Information:
This work was financially supported by JSPS KAKENHI grants JP15H05846 (Middle Molecular Strategy) and JP18H04263 (Precisely Designed Catalysts with Customized Scaffolding), as well as a Grant-in-Aid for Scientific Research (B) (#17H03972), a Grant-in-Aid for Scientific Research (C) (#16K08166), and Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from AMED under grant number JP19am0101091.
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/11/7
Y1 - 2019/11/7
N2 - Alkylarenes, obtained from abundant hydrocarbon feedstock sources, are an attractive starting material for the formation of complex molecular architectures. Conventional activation strategies of the relatively inert sp3-hybridized benzylic C–H bonds usually require relatively harsh conditions and are difficult to apply to the synthesis of fine chemicals. The present review describes recent strategic advances for the activation of benzylic C–H bonds for the catalytic formation of C–C bonds. In particular, two activation methods, i.e., strategies that generate benzylic radicals or benzyl anions, are discussed.
AB - Alkylarenes, obtained from abundant hydrocarbon feedstock sources, are an attractive starting material for the formation of complex molecular architectures. Conventional activation strategies of the relatively inert sp3-hybridized benzylic C–H bonds usually require relatively harsh conditions and are difficult to apply to the synthesis of fine chemicals. The present review describes recent strategic advances for the activation of benzylic C–H bonds for the catalytic formation of C–C bonds. In particular, two activation methods, i.e., strategies that generate benzylic radicals or benzyl anions, are discussed.
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U2 - 10.1016/j.tetlet.2019.151225
DO - 10.1016/j.tetlet.2019.151225
M3 - Review article
AN - SCOPUS:85073003423
VL - 60
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 45
M1 - 151225
ER -