Recipients with shorter cardiopulmonary bypass time achieve improvement of parasympathetic reinnervation within 6 months after heart transplantation

Teruhiko Imamura, Koichiro Kinugawa, Takeo Fujino, Toshiro Inaba, Hisataka Maki, Masaru Hatano, Osamu Kinoshita, Kan Nawata, Shunei Kyo, Minoru Ono

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12 Citations (Scopus)

Abstract

Although cross-sectional late-phase reinnervation in heart transplantation (HTx) recipients has been demonstrated by several earlier studies, early-phase successive analyses especially for parasympathetic reinnervation remain unknown. Successive heart rate variability (HRV) data calculated by the MemCalc power spectral density method were obtained from 16 non-rejection recipients 1-24 weeks after HTx. High frequency (HF) level representing parasympathetic magnitude increased significantly at 6 months after HTx (from 0.9 ± 0.7 to 4.1 ± 2.8 ms2*). Only intraoperative shorter cardiopulmonary bypass time (181 ± 59 minutes) correlated with a higher level of HF at post-HTx 6 months among all baseline variables (r = -0.530*). Higher level of HF was associated with recovery of tachycardia at post-HTx 6 months (r = -0.514*). In conclusion, parasympathetic reinnervation emerges along with recovery of tachycardia < 6 months after HTx, which is accelerated by shorter intraoperative cardiopulmonary bypass time (*P < 0.05 for all).

Original languageEnglish
Pages (from-to)440-444
Number of pages5
JournalInternational Heart Journal
Volume55
Issue number5
DOIs
Publication statusPublished - Jan 1 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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    Imamura, T., Kinugawa, K., Fujino, T., Inaba, T., Maki, H., Hatano, M., Kinoshita, O., Nawata, K., Kyo, S., & Ono, M. (2014). Recipients with shorter cardiopulmonary bypass time achieve improvement of parasympathetic reinnervation within 6 months after heart transplantation. International Heart Journal, 55(5), 440-444. https://doi.org/10.1536/ihj.14-111