Abstract
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), infects one-third of the world's population and causes 1.5 million deaths each year. The cell envelopes of mycobacteria comprise a wealth of unique glycolipids, including trehalose-6,6′-dimycolate (TDM), lipoarabinomannan (LAM), lipomannan (LM), and phosphatidylinositol (PI) mannosides (PIMs). These lipids are important modulators of the host immune responses during infection and in some cases have been used as adjuvants [e.g., complete Freund's adjuvant (CFA)]. Despite this abundant basic knowledge, the identities of the host immune receptors for mycobacterial lipids have long been elusive. Here we review and summarize our current state of knowledge regarding innate immune receptors for mycobacteria, focusing particularly on immunoreceptor tyrosine-based activation motif (ITAM)-coupled C-type lectin receptors (CLRs), which have been shown to recognize mycobacteria-derived glycolipids.
| Original language | English |
|---|---|
| Pages (from-to) | 66-76 |
| Number of pages | 11 |
| Journal | Trends in Immunology |
| Volume | 38 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2017 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
Cite this
Recognition of Mycobacterial Lipids by Immune Receptors. / Ishikawa, Eri; Mori, Daiki; Yamasaki, Sho.
In: Trends in Immunology, Vol. 38, No. 1, 01.01.2017, p. 66-76.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Recognition of Mycobacterial Lipids by Immune Receptors
AU - Ishikawa, Eri
AU - Mori, Daiki
AU - Yamasaki, Sho
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), infects one-third of the world's population and causes 1.5 million deaths each year. The cell envelopes of mycobacteria comprise a wealth of unique glycolipids, including trehalose-6,6′-dimycolate (TDM), lipoarabinomannan (LAM), lipomannan (LM), and phosphatidylinositol (PI) mannosides (PIMs). These lipids are important modulators of the host immune responses during infection and in some cases have been used as adjuvants [e.g., complete Freund's adjuvant (CFA)]. Despite this abundant basic knowledge, the identities of the host immune receptors for mycobacterial lipids have long been elusive. Here we review and summarize our current state of knowledge regarding innate immune receptors for mycobacteria, focusing particularly on immunoreceptor tyrosine-based activation motif (ITAM)-coupled C-type lectin receptors (CLRs), which have been shown to recognize mycobacteria-derived glycolipids.
AB - Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), infects one-third of the world's population and causes 1.5 million deaths each year. The cell envelopes of mycobacteria comprise a wealth of unique glycolipids, including trehalose-6,6′-dimycolate (TDM), lipoarabinomannan (LAM), lipomannan (LM), and phosphatidylinositol (PI) mannosides (PIMs). These lipids are important modulators of the host immune responses during infection and in some cases have been used as adjuvants [e.g., complete Freund's adjuvant (CFA)]. Despite this abundant basic knowledge, the identities of the host immune receptors for mycobacterial lipids have long been elusive. Here we review and summarize our current state of knowledge regarding innate immune receptors for mycobacteria, focusing particularly on immunoreceptor tyrosine-based activation motif (ITAM)-coupled C-type lectin receptors (CLRs), which have been shown to recognize mycobacteria-derived glycolipids.
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UR - http://www.scopus.com/inward/citedby.url?scp=85007173899&partnerID=8YFLogxK
U2 - 10.1016/j.it.2016.10.009
DO - 10.1016/j.it.2016.10.009
M3 - Review article
C2 - 27889398
AN - SCOPUS:85007173899
VL - 38
SP - 66
EP - 76
JO - Trends in Immunology
JF - Trends in Immunology
SN - 1471-4906
IS - 1
ER -