Recognition of Mycobacterial Lipids by Immune Receptors

Eri Ishikawa, Daiki Mori, Sho Yamasaki

    Research output: Contribution to journalReview articlepeer-review

    53 Citations (Scopus)

    Abstract

    Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), infects one-third of the world's population and causes 1.5 million deaths each year. The cell envelopes of mycobacteria comprise a wealth of unique glycolipids, including trehalose-6,6′-dimycolate (TDM), lipoarabinomannan (LAM), lipomannan (LM), and phosphatidylinositol (PI) mannosides (PIMs). These lipids are important modulators of the host immune responses during infection and in some cases have been used as adjuvants [e.g., complete Freund's adjuvant (CFA)]. Despite this abundant basic knowledge, the identities of the host immune receptors for mycobacterial lipids have long been elusive. Here we review and summarize our current state of knowledge regarding innate immune receptors for mycobacteria, focusing particularly on immunoreceptor tyrosine-based activation motif (ITAM)-coupled C-type lectin receptors (CLRs), which have been shown to recognize mycobacteria-derived glycolipids.

    Original languageEnglish
    Pages (from-to)66-76
    Number of pages11
    JournalTrends in Immunology
    Volume38
    Issue number1
    DOIs
    Publication statusPublished - Jan 1 2017

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

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