TY - JOUR
T1 - Recognition of Polymer Terminus by Metal-Organic Frameworks Enabling Chromatographic Separation of Polymers
AU - Mizutani, Nagi
AU - Hosono, Nobuhiko
AU - Le Ouay, Benjamin
AU - Kitao, Takashi
AU - Matsuura, Ryoichirou
AU - Kubo, Takuya
AU - Uemura, Takashi
N1 - Funding Information:
This work was supported by a JST-CREST program (JPMJCR1321) and a Grant-in-Aid for Science Research on Innovative Area “Coordination Asymmetry” (JP16H06517) from the Ministry of Education, Culture, Sports, Science and Technology, Government of Japan. N.H. acknowledges a KAKENHI Grant-in-Aid for Scientific Research (B) (JP18H02072) and Scientific Research on Innovative Areas “Molecular Engine” (JP19H05381).
Publisher Copyright:
Copyright © 2020 American Chemical Society.
PY - 2020/2/26
Y1 - 2020/2/26
N2 - Unlike commonly used molecular recognition techniques, recognition of polymer structures requires an additional aspect of extremely high recognition ability, by which marginal structural differences can be identified in a large polymer chain. Herein we show that metal-organic frameworks (MOFs) can recognize polymer terminal structures, thus enabling the first reported chromatographic separation of polymers. End-functionalized polyethylene glycols (PEGs) are selectively inserted into the MOF channel, the insertion kinetics being dependent on the projection size of the PEG terminus. This size-selective insertion mechanism facilitates precise discrimination of end-functionalized PEGs using liquid chromatography (LC). An MOF-packed column thus provides an efficient and easily accessible method for the separation of such end-functionalized polymers using conventional LC systems.
AB - Unlike commonly used molecular recognition techniques, recognition of polymer structures requires an additional aspect of extremely high recognition ability, by which marginal structural differences can be identified in a large polymer chain. Herein we show that metal-organic frameworks (MOFs) can recognize polymer terminal structures, thus enabling the first reported chromatographic separation of polymers. End-functionalized polyethylene glycols (PEGs) are selectively inserted into the MOF channel, the insertion kinetics being dependent on the projection size of the PEG terminus. This size-selective insertion mechanism facilitates precise discrimination of end-functionalized PEGs using liquid chromatography (LC). An MOF-packed column thus provides an efficient and easily accessible method for the separation of such end-functionalized polymers using conventional LC systems.
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U2 - 10.1021/jacs.9b13568
DO - 10.1021/jacs.9b13568
M3 - Article
C2 - 32037826
AN - SCOPUS:85080973271
SN - 0002-7863
VL - 142
SP - 3701
EP - 3705
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 8
ER -