Recognition of Polymer Terminus by Metal-Organic Frameworks Enabling Chromatographic Separation of Polymers

Nagi Mizutani, Nobuhiko Hosono, Benjamin Le Ouay, Takashi Kitao, Ryoichirou Matsuura, Takuya Kubo, Takashi Uemura

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Unlike commonly used molecular recognition techniques, recognition of polymer structures requires an additional aspect of extremely high recognition ability, by which marginal structural differences can be identified in a large polymer chain. Herein we show that metal-organic frameworks (MOFs) can recognize polymer terminal structures, thus enabling the first reported chromatographic separation of polymers. End-functionalized polyethylene glycols (PEGs) are selectively inserted into the MOF channel, the insertion kinetics being dependent on the projection size of the PEG terminus. This size-selective insertion mechanism facilitates precise discrimination of end-functionalized PEGs using liquid chromatography (LC). An MOF-packed column thus provides an efficient and easily accessible method for the separation of such end-functionalized polymers using conventional LC systems.

Original languageEnglish
Pages (from-to)3701-3705
Number of pages5
JournalJournal of the American Chemical Society
Volume142
Issue number8
DOIs
Publication statusPublished - Feb 26 2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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