Recombinant LD78 protein, a member of the small cytokine family, enhances osteoclast differentiation in rat bone marrow culture system

Toshio Kukita, Junji Nakao, Fukusaburo Hamada, Akiko Kukita, Tetsuichiro Inai, Kojiro Kurisu, Hisayuki Nomiyama

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Cytokine LD78 is a member of the small inducible protein family involved in cell growth, wound healing and inflammation. However, its exact function is not known. In this study, we demonstrated that recombinant LD78α and its variant LD78β proteins stimulate osteoclast-like cell formation in rat bone marrow cultures in the presence of 1α,25-dihydroxyvitamin D3. This enhancing activity was independent of prostaglandin synthesis. This is the first report which describes the effect of proteins involved in the small inducible protein family on the differentiation of osteoclasts.

Original languageEnglish
Pages (from-to)215-223
Number of pages9
JournalBone and Mineral
Volume19
Issue number3
DOIs
Publication statusPublished - Dec 1992

All Science Journal Classification (ASJC) codes

  • Surgery
  • Biochemistry
  • Endocrinology

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