Recombinant LD78 protein, a member of the small cytokine family, enhances osteoclast differentiation in rat bone marrow culture system

Toshio Kukita; Junji Nakao; Fukusaburo Hamada; Akiko Kukita; Tetsuichiro Inai; Kojiro Kurisu; Hisayuki Nomiyama

doi:10.1016/0169-6009(92)90871-A

Recombinant LD78 protein, a member of the small cytokine family, enhances osteoclast differentiation in rat bone marrow culture system

Toshio Kukita, Junji Nakao, Fukusaburo Hamada, Akiko Kukita, Tetsuichiro Inai, Kojiro Kurisu, Hisayuki Nomiyama

Oral Biological Sciences

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21 Citations (Scopus)

Abstract

Cytokine LD78 is a member of the small inducible protein family involved in cell growth, wound healing and inflammation. However, its exact function is not known. In this study, we demonstrated that recombinant LD78α and its variant LD78β proteins stimulate osteoclast-like cell formation in rat bone marrow cultures in the presence of 1α,25-dihydroxyvitamin D₃. This enhancing activity was independent of prostaglandin synthesis. This is the first report which describes the effect of proteins involved in the small inducible protein family on the differentiation of osteoclasts.

Original language	English
Pages (from-to)	215-223
Number of pages	9
Journal	Bone and Mineral
Volume	19
Issue number	3
DOIs	https://doi.org/10.1016/0169-6009(92)90871-A
Publication status	Published - Dec 1992

All Science Journal Classification (ASJC) codes

Surgery
Biochemistry
Endocrinology

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title = "Recombinant LD78 protein, a member of the small cytokine family, enhances osteoclast differentiation in rat bone marrow culture system",

abstract = "Cytokine LD78 is a member of the small inducible protein family involved in cell growth, wound healing and inflammation. However, its exact function is not known. In this study, we demonstrated that recombinant LD78α and its variant LD78β proteins stimulate osteoclast-like cell formation in rat bone marrow cultures in the presence of 1α,25-dihydroxyvitamin D3. This enhancing activity was independent of prostaglandin synthesis. This is the first report which describes the effect of proteins involved in the small inducible protein family on the differentiation of osteoclasts.",

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T1 - Recombinant LD78 protein, a member of the small cytokine family, enhances osteoclast differentiation in rat bone marrow culture system

AU - Kukita, Toshio

AU - Nakao, Junji

AU - Hamada, Fukusaburo

AU - Kukita, Akiko

AU - Inai, Tetsuichiro

AU - Kurisu, Kojiro

AU - Nomiyama, Hisayuki

PY - 1992/12

Y1 - 1992/12

N2 - Cytokine LD78 is a member of the small inducible protein family involved in cell growth, wound healing and inflammation. However, its exact function is not known. In this study, we demonstrated that recombinant LD78α and its variant LD78β proteins stimulate osteoclast-like cell formation in rat bone marrow cultures in the presence of 1α,25-dihydroxyvitamin D3. This enhancing activity was independent of prostaglandin synthesis. This is the first report which describes the effect of proteins involved in the small inducible protein family on the differentiation of osteoclasts.

AB - Cytokine LD78 is a member of the small inducible protein family involved in cell growth, wound healing and inflammation. However, its exact function is not known. In this study, we demonstrated that recombinant LD78α and its variant LD78β proteins stimulate osteoclast-like cell formation in rat bone marrow cultures in the presence of 1α,25-dihydroxyvitamin D3. This enhancing activity was independent of prostaglandin synthesis. This is the first report which describes the effect of proteins involved in the small inducible protein family on the differentiation of osteoclasts.

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Recombinant LD78 protein, a member of the small cytokine family, enhances osteoclast differentiation in rat bone marrow culture system

Abstract

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