Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer

Pamela S. Ohashi, Tak W. Mak, Peter Van Den Elsen, Yusuke Yanagi, Yasunobu Yoshikai, Andrew F. Calman, Cox Terhorst, John D. Stobo, Arthur Weiss

Research output: Contribution to journalArticlepeer-review

189 Citations (Scopus)

Abstract

We have introduced a full-length complementary DNA of the T-cell antigen receptor β-chain into a mutant human T-cell line that lacked a complete β-chain messenger RNA, had a diminished level of α-chain transcript and did not express surface T3- or antigen receptor. Expression of the transfected β-chain led to a normal level of α-chain transcript and a structurally and functionally active T3 T-cell antigen receptor complex on the cell surface.

Original languageEnglish
Pages (from-to)606-609
Number of pages4
JournalNature
Volume316
Issue number6029
DOIs
Publication statusPublished - 1985
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

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