Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer

Pamela S. Ohashi, Tak W. Mak, Peter Van Den Elsen, Yusuke Yanagi, Yasunobu Yoshikai, Andrew F. Calman, Cox Terhorst, John D. Stobo, Arthur Weiss

    Research output: Contribution to journalArticle

    188 Citations (Scopus)

    Abstract

    We have introduced a full-length complementary DNA of the T-cell antigen receptor β-chain into a mutant human T-cell line that lacked a complete β-chain messenger RNA, had a diminished level of α-chain transcript and did not express surface T3- or antigen receptor. Expression of the transfected β-chain led to a normal level of α-chain transcript and a structurally and functionally active T3 T-cell antigen receptor complex on the cell surface.

    Original languageEnglish
    Pages (from-to)606-609
    Number of pages4
    JournalNature
    Volume316
    Issue number6029
    DOIs
    Publication statusPublished - Dec 1 1985

    All Science Journal Classification (ASJC) codes

    • General

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  • Cite this

    Ohashi, P. S., Mak, T. W., Van Den Elsen, P., Yanagi, Y., Yoshikai, Y., Calman, A. F., Terhorst, C., Stobo, J. D., & Weiss, A. (1985). Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer. Nature, 316(6029), 606-609. https://doi.org/10.1038/316606a0